{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Silverman HE"],"funding":["NIA NIH HHS","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["1635-1649"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9160199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(9)"],"pubmed_abstract":["<h4>Introduction</h4>Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.<h4>Methods</h4>In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.<h4>Results</h4>Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In ad"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["The contribution of behavioral features to caregiver burden in FTLD spectrum disorders."],"pmcid":["PMC9160199"],"funding_grant_id":["U54 NS092089","P01 AG019724","P30 AG066507","K24 AG045333","R01 AG038791","U24 AG021886","P30 AG066462","U01 AG045390","U01 AG079850","U24 AG056270","R01 AG062268","R01 MH120794","U19 AG063911"],"pubmed_authors":["Kornak J","Lapid MI","Graff-Radford NR","Goldman JS","Forsberg LK","Rosen HJ","Huey ED","Ghoshal N","Litvan I","Ake JM","Boxer AL","Boeve BF","Cosentino S","Manoochehri M","Silverman HE","Dickerson BC","Pascual B","ALLFTD consortium","Appleby BS","Devick KL","Grossman M","Mendez MF","Fields JA","Barker MS","Brushaber D","Mackenzie IR","Onyike CU","Tartaglia MC","Heuer HW"],"additional_accession":[]},"is_claimable":false,"name":"The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.","description":"<h4>Introduction</h4>Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.<h4>Methods</h4>In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.<h4>Results</h4>Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In ad","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-12T15:07:06.47Z","creation":"2025-04-04T23:45:26.8Z"},"accession":"S-EPMC9160199","cross_references":{"pubmed":["34854532"],"doi":["10.1002/alz.12494"]}}