biostudies-literatureSilverman HENIA NIH HHSNIMH NIH HHSNINDS NIH HHS1635-1649https://www.ebi.ac.uk/biostudies/studies/S-EPMC9160199biostudies-literatureUnknown18(9)<h4>Introduction</h4>Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.<h4>Methods</h4>In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.<h4>Results</h4>Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In adAlzheimer's & dementia : the journal of the Alzheimer's AssociationThe contribution of behavioral features to caregiver burden in FTLD spectrum disorders.PMC9160199U54 NS092089P01 AG019724P30 AG066507K24 AG045333R01 AG038791U24 AG021886P30 AG066462U01 AG045390U01 AG079850U24 AG056270R01 AG062268R01 MH120794U19 AG063911Kornak JLapid MIGraff-Radford NRGoldman JSForsberg LKRosen HJHuey EDGhoshal NLitvan IAke JMBoxer ALBoeve BFCosentino SManoochehri MSilverman HEDickerson BCPascual BALLFTD consortiumAppleby BSDevick KLGrossman MMendez MFFields JABarker MSBrushaber DMackenzie IROnyike CUTartaglia MCHeuer HWfalseThe contribution of behavioral features to caregiver burden in FTLD spectrum disorders.<h4>Introduction</h4>Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.<h4>Methods</h4>In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.<h4>Results</h4>Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In ad2022-01-01T00:00:00Z2022 Sep2026-04-12T15:07:06.47Z2025-04-04T23:45:26.8ZS-EPMC91601993485453210.1002/alz.12494