biostudies-literatureUnknown52(6)Cha JJ<h4>Background and objectives</h4>Endovascular therapy (EVT) first strategy has been widely adopted for the treatment of chronic limb threatening ischemia (CLTI) patients in real-world practice. This study aimed to investigate long-term outcomes of CLTI patients who underwent EVT and identify prognostic factors.<h4>Methods</h4>From the retrospective cohorts of a Korean multicenter endovascular therapy registry, 1,036 patients with CLTI (792 men, 68.8 ± 9.5 years) were included. The primary endpoint was amputation-free survival (AFS) defined as the absence of major amputation or death. Secondary endpoints were major adverse limb events (MALE; a composite of major amputation, minor amputation, and reintervention).<h4>Results</h4>Five-year AFS and freedom from MALE were 69.8% and 61%, respectKorean circulation journal429-440https://www.ebi.ac.uk/biostudies/studies/S-EPMC9160641biostudies-literatureLong-term Clinical Outcomes and Prognostic Factors After Endovascular Treatment in Patients With Chronic Limb Threatening Ischemia.PMC9160641Choi DYu CWKim HK-VIS (Korean Vascular Intervention Society) investigatorsChae IHKoh YSYoon CHChoi SHKim JYLee SWMin PKKo YGLee SRCha JJLee JHfalseLong-term Clinical Outcomes and Prognostic Factors After Endovascular Treatment in Patients With Chronic Limb Threatening Ischemia.<h4>Background and objectives</h4>Endovascular therapy (EVT) first strategy has been widely adopted for the treatment of chronic limb threatening ischemia (CLTI) patients in real-world practice. This study aimed to investigate long-term outcomes of CLTI patients who underwent EVT and identify prognostic factors.<h4>Methods</h4>From the retrospective cohorts of a Korean multicenter endovascular therapy registry, 1,036 patients with CLTI (792 men, 68.8 ± 9.5 years) were included. The primary endpoint was amputation-free survival (AFS) defined as the absence of major amputation or death. Secondary endpoints were major adverse limb events (MALE; a composite of major amputation, minor amputation, and reintervention).<h4>Results</h4>Five-year AFS and freedom from MALE were 69.8% and 61%, respect2022-01-01T00:00:00Z2022 Jun2026-04-08T11:09:28.082Z2025-02-19T02:44:07.279ZS-EPMC91606413525752210.4070/kcj.2021.0342