{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Romaldini A"],"pubmed_abstract":["The impact of graphene oxide on hepatic functional cells represents a crucial evaluation step for its potential application in nanomedicine. Primary human hepatocytes are the gold standard for studying drug toxicity and metabolism; however, current technical limitations may slow down the large-scale diffusion of this cellular tool for <i>in vitro</i> investigations. To assess the potential hepatotoxicity of graphene oxide, we propose an alternative cell model, the second-generation upcyte<sup>®</sup> hepatocytes, which show metabolic and functional profiles akin to primary human hepatocytes. Cells were acutely exposed to sub-lethal concentrations of graphene oxide (≤80 μg/ml) for 24 h and stress-related cell responses (such as apoptosis, oxidative stress, and inflammatory response) were ev"],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["867728"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9161028"],"repository":["biostudies-literature"],"pubmed_title":["Sub-Lethal Concentrations of Graphene Oxide Trigger Acute-Phase Response and Impairment of Phase-I Xenobiotic Metabolism in Upcyte<sup>®</sup> Hepatocytes."],"pmcid":["PMC9161028"],"pubmed_authors":["Sabella S","Romaldini A","Poggi A","Catalano F","Spano R","Villa F"],"additional_accession":[]},"is_claimable":false,"name":"Sub-Lethal Concentrations of Graphene Oxide Trigger Acute-Phase Response and Impairment of Phase-I Xenobiotic Metabolism in Upcyte<sup>®</sup> Hepatocytes.","description":"The impact of graphene oxide on hepatic functional cells represents a crucial evaluation step for its potential application in nanomedicine. Primary human hepatocytes are the gold standard for studying drug toxicity and metabolism; however, current technical limitations may slow down the large-scale diffusion of this cellular tool for <i>in vitro</i> investigations. To assess the potential hepatotoxicity of graphene oxide, we propose an alternative cell model, the second-generation upcyte<sup>®</sup> hepatocytes, which show metabolic and functional profiles akin to primary human hepatocytes. Cells were acutely exposed to sub-lethal concentrations of graphene oxide (≤80 μg/ml) for 24 h and stress-related cell responses (such as apoptosis, oxidative stress, and inflammatory response) were ev","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:06:42.315Z","creation":"2024-11-13T05:15:22.642Z"},"accession":"S-EPMC9161028","cross_references":{"pubmed":["35662849"],"doi":["10.3389/fbioe.2022.867728"]}}