{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sui S"],"funding":["Major Science and Technology Program of Changzhou Health Commission in 2020","Project of Changzhou Medical Innovation Team"],"pagination":["10617-10628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9161985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Pancreatic cancer (PC) is a life-threatening cancer with increasing incidence in developed countries. Reports indicate that tRNA-derived fragments (tRFs) are possible therapeutic targets and biomarkers for cancer treatment. Nonetheless, the effect of tRF-Leu-AAG on PC is unclear. This study aims to explore the role of tRF-Leu-AAG and upstream frameshift mutant 1 (UPF1) in the development of PC and its potential underlying mechanisms. High-throughput second-generation sequencing techniques were used to detect the expression of tRFs in cancerous and adjacent normal tissues from PC patients. The role of tRF-Leu-AAG proliferation in PC cells was investigated via the Cell Counting Kit-8 (CCK8) assay. The effect of tRF-Leu-AAG on the invasion and migration ability of PC cells was also determined"],"journal":["Bioengineered"],"pubmed_title":["The biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells."],"pmcid":["PMC9161985"],"funding_grant_id":["ZD202023","CCX201807"],"pubmed_authors":["Sui S","Cui X","Wang Z","Jin L","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"The biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells.","description":"Pancreatic cancer (PC) is a life-threatening cancer with increasing incidence in developed countries. Reports indicate that tRNA-derived fragments (tRFs) are possible therapeutic targets and biomarkers for cancer treatment. Nonetheless, the effect of tRF-Leu-AAG on PC is unclear. This study aims to explore the role of tRF-Leu-AAG and upstream frameshift mutant 1 (UPF1) in the development of PC and its potential underlying mechanisms. High-throughput second-generation sequencing techniques were used to detect the expression of tRFs in cancerous and adjacent normal tissues from PC patients. The role of tRF-Leu-AAG proliferation in PC cells was investigated via the Cell Counting Kit-8 (CCK8) assay. The effect of tRF-Leu-AAG on the invasion and migration ability of PC cells was also determined","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T11:53:33.373Z","creation":"2025-04-06T00:05:34.16Z"},"accession":"S-EPMC9161985","cross_references":{"pubmed":["35442152"],"doi":["10.1080/21655979.2022.2064206"]}}