biostudies-literatureSingh BMedical Research CouncilHorizon 2020National Institute for Health Research (NIHR)e0263595https://www.ebi.ac.uk/biostudies/studies/S-EPMC9162376biostudies-literatureUnknown17(6)<h4>Background</h4>Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome.<h4>Methods</h4>We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) PloS onePrognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.PMC9162376MR/V033441/1NIHR200907ACF-2020-07-00373458417/63/1117/63/110D'Anna LPaterson RAbdelnour LHGarcia Garcia SHey SRavaglia SHassell JCividini SAzab MAHeyse ABrito Ferreira MLNicholson TRRocha Ferreira Da Silva IChandratheva ACavallieri FFoschi MPatrick KNJain RCabreira VUginet MDefres SGunasekaran KPoxon JBanks TSoothill GDu Pasquier RSarmati LFernandez Diaz ESolomon TPadovani ABiagio Mercuri NMorrison HDervisevic SEscalard SCorvol JCDhar SGiunta MMartinez-Poles JMorales-Casado MINalleballe KFajardo Modol AServidei SDavies EKaya YSargent BFTattevin PRice CBernard-Valnet RMariotto SFarooq HHodel EMCattrall JWSBeretta SLopez ECSantoro JChinthapalli KYounas KSejvar JJKaimovsky IBrain Infections Global COVID-Neuro Network Study GroupLiguori CNortley RAbd-Allah FSeyedAlinaghi SMason RHuda SCohen MWebb GValdoleiros SRSingh BNancupil Reyes WKim CYHornuss DLahiri DGarazzino SGuekht AMeza RGuijarro-Castro CMhlanga SPrimiano GCoen MBenger MKassahun DLipunga GCalabresi PScullen TBeach SRabas SContini EMatos AMBKlok FASomasundaran APilotto AElicer IHarte JWerring DJWinkler ASZedde MCysique LBoso FAlkeridy WMinton TWagner DEnright NLibri IThakur KTMond GKahn LTudur Smith CPinto ACostache OLant SLingor PJillella DKhawaja AElkady ABabu HDelorme CHosp JHarkness Kvan Pesch VBigaut KRieg SKnier BSoares CNBreville GPincherle ADiezma-Martin AMBrew BRaith ETamborska AEugenin-von Bernhardi LRawlinson RJamaliMoghadamSiahkali SMoein STBarrios-Lopez JMKoh JBenjamin LLechien JMaggi PUmapathi TKarthikappallil DYin RLorenz NAl Sami YOliveira VMorassi MYenkoyan KMichael BDPierantozzi MSaussez SZhang XBeltran-Corbellini ASztriha LJoseph ASharifi-Razavi AGoodwin LCfalsePrognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.<h4>Background</h4>Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome.<h4>Methods</h4>We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) 2022-01-01T00:00:00Z20222025-04-26T03:21:31.29Z2025-02-19T03:21:27.751ZS-EPMC91623763565333010.1371/journal.pone.0263595