{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kulyte A"],"funding":["Medical Research Council"],"pagination":["1350-1362"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9163556"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71(6)"],"pubmed_abstract":["Interindividual differences in generation of new fat cells determine body fat and type 2 diabetes risk. In the GENetics of Adipocyte Lipolysis (GENiAL) cohort, which consists of participants who have undergone abdominal adipose biopsy, we performed a genome-wide association study (GWAS) of fat cell number (n = 896). Candidate genes from the genetic study were knocked down by siRNA in human adipose-derived stem cells. We report 318 single nucleotide polymorphisms (SNPs) and 17 genetic loci displaying suggestive (P < 1 × 10-5) association with fat cell number. Two loci pass threshold for GWAS significance, on chromosomes 2 (lead SNP rs149660479-G) and 7 (rs147389390-deletion). We filtered for fat cell number-associated SNPs (P < 1.00 × 10-5) using evidence of genotype-specific expression. Wh"],"journal":["Diabetes"],"pubmed_title":["Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 Diabetes."],"pmcid":["PMC9163556"],"funding_grant_id":["MR/S003061/1"],"pubmed_authors":["Arner P","Kulyte A","Aman A","Strawbridge RJ","Dahlman IA"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 Diabetes.","description":"Interindividual differences in generation of new fat cells determine body fat and type 2 diabetes risk. In the GENetics of Adipocyte Lipolysis (GENiAL) cohort, which consists of participants who have undergone abdominal adipose biopsy, we performed a genome-wide association study (GWAS) of fat cell number (n = 896). Candidate genes from the genetic study were knocked down by siRNA in human adipose-derived stem cells. We report 318 single nucleotide polymorphisms (SNPs) and 17 genetic loci displaying suggestive (P < 1 × 10-5) association with fat cell number. Two loci pass threshold for GWAS significance, on chromosomes 2 (lead SNP rs149660479-G) and 7 (rs147389390-deletion). We filtered for fat cell number-associated SNPs (P < 1.00 × 10-5) using evidence of genotype-specific expression. Wh","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-05-18T12:27:36.797Z","creation":"2025-02-19T03:27:22.542Z"},"accession":"S-EPMC9163556","cross_references":{"pubmed":["35320353"],"doi":["10.2337/db21-0804"]}}