{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vogelezang S"],"funding":["NICHD NIH HHS","The Daniel B. Burke Endowed Chair for Diabetes Research","NNF Center for Basic Metabolic Research","NIH","Netherlands Organization for Health Research and Development","European Research Council","Institute Development Award from the Children’s Hospital of Philadelphia","NIDDK NIH HHS","Medical Research Council","Research Development Award from the Cotswold Foundation","National Institute for Health Research (NIHR)","Children’s Hospital of Philadelphia Endowed Chair in Genomic Research","Wellcome Trust","Novo Nordisk Fonden"],"pagination":["124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166310"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Head circumference is associated with intelligence and tracks from childhood into adulthood.<h4>Methods</h4>We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.<h4>Results</h4>Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.<h4>Conclusions</h4>The results of this study indicate that the biological processes underlying e"],"journal":["BMC medical genomics"],"pubmed_title":["Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes."],"pmcid":["PMC9166310"],"funding_grant_id":["NNF19OC0057445","293574","104150/Z/14/Z","NNF21OC0070349","NNF15OC0016108","Grarup Group","MC_UU_12013/3","217065/Z/19/Z","NNF18OC0054741","202802/Z/16/Z","VIDI 016.136.361","MC_PC_15018","Hansen Group","G9815508","MC_UU_00011/1","U01 DK105535","R01 HD056465","NNF20OC0063872","Phenomics","ERC-2014-CoG-648916","G0600705","NF-SI-0617-10090","NNF17OC0027492","322605","648916","098051","MC_PC_19009"],"pubmed_authors":["McCarthy MI","Johansson S","Uitterlinden AG","Atalay M","Ramdas S","Rifas-Shiman SL","Lind MV","Michaelsen KF","Wang C C","Lauritzen L","Bonnelykke K","Melbye M","Njolstad PR","Escribano J","Geller F","Raitakari OT","Hivert MF","Schnurr TM","Langhendries JP","Stergiakouli E","Felix JF","Standl M","Hattersley AT","Niinikoski H","Adams HHH","Zeggini E","Holm JC","Panoutsopoulou K","Waldenberger M","Vrijkotte TGM","Dedoussis GV","Vonk JM","Nohr EA","Vrijheid M","Timpson NJ","Jaddoe VWV","Widen E","Iniguez C","Casas M","Vogel M","Evans TE","Holloway J","Knol MJ","Janjanam VD","Bradfield JP","Rivadeneira F","Fernandez-Jimenez N","Bisgaard H","Junna N","Vogelezang S","Morgen CS","Early Growth Genetics Consortium","Pourcain BS","Grarup N","Rzehak P","Knight BA","Sebert S","Lakka TA","Scholtens D","Geoffrey Hayes M","Pennell CE","Joro R","Grant SFA","Tamayo I","Vinding R","Brown C","Feenstra B","Vaudel M","Bilbao JR","Leinonen JT","Lund MAV","Koppelman GH","Ahluwalia TS","Zafarmand MH","Grote V","Thiering E","Pitkanen N","Bacelis J","Lin FTJ","Koletzko B","Eriksson JG","Lindi V","Jarvelin MR","Pahkala K","Hakonarson H","Frithioff-Bojsoe C","Freathy RM","Karhunen V","Verduci E","Beaumont RN","Helgeland O","Liu X","Juodakis J","Jacobsson B","Gehring U","Gruszfeld D","Karmaus W","Lowe WL","Kiess W","Korner A","Herrala S","Scholz M","Beilin L","Pedersen O","Heinrich J","Lye S","Schaik BDC","Hansen T","Santa-Marina L","Torrent M","Ntalla I","Have CT"],"additional_accession":[]},"is_claimable":false,"name":"Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.","description":"<h4>Background</h4>Head circumference is associated with intelligence and tracks from childhood into adulthood.<h4>Methods</h4>We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.<h4>Results</h4>Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.<h4>Conclusions</h4>The results of this study indicate that the biological processes underlying e","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-09T18:59:13.569Z","creation":"2024-11-13T17:41:11.71Z"},"accession":"S-EPMC9166310","cross_references":{"pubmed":["35659227"],"doi":["10.1186/s12920-022-01281-1"]}}