biostudies-literatureVogelezang SNICHD NIH HHSThe Daniel B. Burke Endowed Chair for Diabetes ResearchNNF Center for Basic Metabolic ResearchNIHNetherlands Organization for Health Research and DevelopmentEuropean Research CouncilInstitute Development Award from the Children’s Hospital of PhiladelphiaNIDDK NIH HHSMedical Research CouncilResearch Development Award from the Cotswold FoundationNational Institute for Health Research (NIHR)Children’s Hospital of Philadelphia Endowed Chair in Genomic ResearchWellcome TrustNovo Nordisk Fonden124https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166310biostudies-literatureUnknown15(1)<h4>Background</h4>Head circumference is associated with intelligence and tracks from childhood into adulthood.<h4>Methods</h4>We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.<h4>Results</h4>Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.<h4>Conclusions</h4>The results of this study indicate that the biological processes underlying eBMC medical genomicsGenetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.PMC9166310NNF19OC0057445293574104150/Z/14/ZNNF21OC0070349NNF15OC0016108Grarup GroupMC_UU_12013/3217065/Z/19/ZNNF18OC0054741202802/Z/16/ZVIDI 016.136.361MC_PC_15018Hansen GroupG9815508MC_UU_00011/1U01 DK105535R01 HD056465NNF20OC0063872PhenomicsERC-2014-CoG-648916G0600705NF-SI-0617-10090NNF17OC0027492322605648916098051MC_PC_19009McCarthy MIJohansson SUitterlinden AGAtalay MRamdas SRifas-Shiman SLLind MVMichaelsen KFWang C CLauritzen LBonnelykke KMelbye MNjolstad PREscribano JGeller FRaitakari OTHivert MFSchnurr TMLanghendries JPStergiakouli EFelix JFStandl MHattersley ATNiinikoski HAdams HHHZeggini EHolm JCPanoutsopoulou KWaldenberger MVrijkotte TGMDedoussis GVVonk JMNohr EAVrijheid MTimpson NJJaddoe VWVWiden EIniguez CCasas MVogel MEvans TEHolloway JKnol MJJanjanam VDBradfield JPRivadeneira FFernandez-Jimenez NBisgaard HJunna NVogelezang SMorgen CSEarly Growth Genetics ConsortiumPourcain BSGrarup NRzehak PKnight BASebert SLakka TAScholtens DGeoffrey Hayes MPennell CEJoro RGrant SFATamayo IVinding RBrown CFeenstra BVaudel MBilbao JRLeinonen JTLund MAVKoppelman GHAhluwalia TSZafarmand MHGrote VThiering EPitkanen NBacelis JLin FTJKoletzko BEriksson JGLindi VJarvelin MRPahkala KHakonarson HFrithioff-Bojsoe CFreathy RMKarhunen VVerduci EBeaumont RNHelgeland OLiu XJuodakis JJacobsson BGehring UGruszfeld DKarmaus WLowe WLKiess WKorner AHerrala SScholz MBeilin LPedersen OHeinrich JLye SSchaik BDCHansen TSanta-Marina LTorrent MNtalla IHave CTfalseGenetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.<h4>Background</h4>Head circumference is associated with intelligence and tracks from childhood into adulthood.<h4>Methods</h4>We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.<h4>Results</h4>Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.<h4>Conclusions</h4>The results of this study indicate that the biological processes underlying e2022-01-01T00:00:00Z2022 Jun2026-05-09T18:59:13.569Z2024-11-13T17:41:11.71ZS-EPMC91663103565922710.1186/s12920-022-01281-1