{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Riberholt CG"],"pubmed_abstract":["<h4>Background</h4>Adequately conducted systematic reviews with meta-analyses are considered the highest level of evidence and thus directly defines many clinical guidelines. However, the risks of type I and II errors in meta-analyses are substantial. Trial Sequential Analysis is a method for controlling these risks. Erroneous use of the method might lead to research waste or misleading conclusions.<h4>Methods</h4>The current protocol describes a systematic review aimed to identify common and major mistakes and errors in the use of Trial Sequential Analysis by evaluating published systematic reviews and meta-analyses that include this method. We plan to include all studies using Trial Sequential Analysis published from January 2018 to January 2022, an estimated 400 to 600 publications. We "],"journal":["Systematic reviews"],"pagination":["114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166392"],"repository":["biostudies-literature"],"pubmed_title":["Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses - protocol for a systematic review."],"pmcid":["PMC9166392"],"pubmed_authors":["Olsen MH","Milan JB","Riberholt CG","Gluud C"],"additional_accession":[]},"is_claimable":false,"name":"Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses - protocol for a systematic review.","description":"<h4>Background</h4>Adequately conducted systematic reviews with meta-analyses are considered the highest level of evidence and thus directly defines many clinical guidelines. However, the risks of type I and II errors in meta-analyses are substantial. Trial Sequential Analysis is a method for controlling these risks. Erroneous use of the method might lead to research waste or misleading conclusions.<h4>Methods</h4>The current protocol describes a systematic review aimed to identify common and major mistakes and errors in the use of Trial Sequential Analysis by evaluating published systematic reviews and meta-analyses that include this method. We plan to include all studies using Trial Sequential Analysis published from January 2018 to January 2022, an estimated 400 to 600 publications. We ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-21T14:12:01.938Z","creation":"2025-04-21T14:12:01.938Z"},"accession":"S-EPMC9166392","cross_references":{"pubmed":["35659769"],"doi":["10.1186/s13643-022-01987-4"]}}