biostudies-literatureLemarechal JDEuropean Research Council under the European Union's Seventh Framework ProgrammeSwiss National Science FoundationFrench ‘Investissements d’avenir’ programmeEuropean Research CouncilF-TRACT, the European Union’s Horizon 2020 Framework Programme for Research and Innovation under Specific1653-1667https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166555biostudies-literatureUnknown145(5)Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-cortical evoked potentials provide a unique window on functional brain networks because they contain sufficient information to infer dynamical properties of large-scale brain connectivity, such as preferred directionality and propagation latencies.  Here, we developed a biologically informed modelling approach to estimate the neural physiological parameters of brain functional networks from the cortico-cortical evoked potentials recorded in a large multicentric database. Specifically, we considered each cortico-cortical evoked potential as the output of a Brain : a journal of neurologyA brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials.PMC9166555No. 785907 and 945539170873ANR-11-INBS-0006 and ANR-10-IAIHU-06616268FP/2007–2013#CRSII5_170873Catenoix HMindruta IMetsahonkala LTuyisenge VDubeau FMenard DSartori ITassi LBouilleret VJob ASDolezalova IPaola Valenti MBartolomei FDussaule CGang HPail MHua LRheims SMaillard LF-TRACT consortiumJonas JIsnard JBourgeois MBlauwblomme TBarba CGeorge NFrancione SNica AWei ZMai RDenuelle MJedynak MTrebaul LNabbout RMasnou PGuerrini RMcGonigal AChanteloup-Foret BGarces MHugues EPrincipe ATaussig DZhou WLey MBiraben AChipaux MWensheng WGotman JDan ZReyes Mejia GCRyvlin PSchulze-Bonhage AXiangshu HMetsahonkala ELAdam CWang HCurot JPetrescu AMSzurhaj WPeltola MTyvaert LAyoubian LScholly JMaria Petrescu AVignal JPMinotti LSingh RValton LKahane PKuba RHirsch ELandre ELemarechal JDZouglech Rde Montaudoin MBoyer ADeman PRocamora RYigang FKocvarova JKaminska ALauronen LNacci ETrebuchon ATourbier SMichel VChochois MMontavont ATadel FChassoux FLiu SQuirins MHagmann PXi MAupy JQiang GDavid OBrazdil MBhattacharjee MSaubat CValentin ANavarro VLenge MNobili LGaily EBarborica ADerambure PfalseA brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials.Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-cortical evoked potentials provide a unique window on functional brain networks because they contain sufficient information to infer dynamical properties of large-scale brain connectivity, such as preferred directionality and propagation latencies.  Here, we developed a biologically informed modelling approach to estimate the neural physiological parameters of brain functional networks from the cortico-cortical evoked potentials recorded in a large multicentric database. Specifically, we considered each cortico-cortical evoked potential as the output of a 2022-01-01T00:00:00Z2022 Jun2025-04-05T13:33:33.501Z2025-04-05T13:33:33.501ZS-EPMC91665553541694210.1093/brain/awab362