biostudies-literatureLopez-Cuenca Iministerio de ciencia, innovación y universidadesministerio de economía y competitividaduniversidad complutense de madridinstituto de salud carlos iiiministerio de ciencia e innovación79https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166601biostudies-literatureUnknown14(1)<h4>Background</h4>Two main genetic risks for sporadic Alzheimer's disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous system and share pathophysiological mechanisms in AD.<h4>Methods</h4>We performed a cross-sectional study with 30 participants without a family history of sporadic AD (FH-) and noncarriers of ApoE ɛ4 (ApoE ɛ4-) as a control group and 34 participants with a family history of sporadic AD (FH+) and carriers of at least one ɛ4 allele (ApoE ɛ4+). We analyzed the correlations between macular volumes of retinal layers and thickness of the peripapillary retinal nerve fiber layer (pRNFL) measured by optical coherence tomography (OCT) with the brain area parameters measured by magnetic resonance imaging (MRI) in pAlzheimer's research & therapyThe relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer's disease: an exploratory analysis.PMC9166601RD16/0008/0005PSI2015 68793-C3-1-RCT82/20-CT83/20FPU17/01023RED2018-102499-TCT42/18-CT43/18Gil PBarabash AMarcos-Dolado AElvira-Hurtado LSalazar JJSanchez-Puebla LRamirez-Torano FYus-Fuertes MArrazola-Garcia JGil-Martinez LLopez-Cuenca ISalobrar-Garcia ERamirez JMFernandez-Albarral JAde Hoz RFuentes-Ferrer MERamirez AIfalseThe relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer's disease: an exploratory analysis.<h4>Background</h4>Two main genetic risks for sporadic Alzheimer's disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous system and share pathophysiological mechanisms in AD.<h4>Methods</h4>We performed a cross-sectional study with 30 participants without a family history of sporadic AD (FH-) and noncarriers of ApoE ɛ4 (ApoE ɛ4-) as a control group and 34 participants with a family history of sporadic AD (FH+) and carriers of at least one ɛ4 allele (ApoE ɛ4+). We analyzed the correlations between macular volumes of retinal layers and thickness of the peripapillary retinal nerve fiber layer (pRNFL) measured by optical coherence tomography (OCT) with the brain area parameters measured by magnetic resonance imaging (MRI) in p2022-01-01T00:00:00Z2022 Jun2026-05-09T18:59:27.942Z2024-11-13T17:41:18.881ZS-EPMC91666013565905410.1186/s13195-022-01008-5