{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Wada T"],"pubmed_abstract":["Disseminated intravascular coagulation (DIC) is one of the major organ dysfunctions associated with sepsis. This retrospective secondary analysis comprised data from a prospective multicenter study to investigate the age-related differences in the survival benefit of anticoagulant therapy in sepsis according to the DIC diagnostic criteria. Adult patients with severe sepsis based on the Sepsis-2 criteria were enrolled and divided into the following groups: (1) anticoagulant group (patients who received anticoagulant therapy) and (2) non-anticoagulant group (patients who did not receive anticoagulant therapy). Patients in the former group were administered antithrombin, recombinant human thrombomodulin, or their combination. The increases in the risk of hospital mortality were suppressed in "],"journal":["Scientific reports"],"pagination":["9304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166729"],"repository":["biostudies-literature"],"pubmed_title":["Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis."],"pmcid":["PMC9166729"],"pubmed_authors":["Sasaki J","Tarui T","Shiraishi SI","Shiraishi A","Takeyama N","Masuno T","Saitoh D","Fujimi S","Tsuruta R","Kotani J","Wada T","Ogura H","Ueyama M","Okamoto K","Fujishima S","Otomo Y","Umemura Y","Takuma K","Hagiwara A","Gando S","Yamakawa K","Kushimoto S","Sakamoto Y","Ikeda H","Mayumi T","Hifumi T","Kabata D","Abe T","Nakada TA","Shiino Y","Yamashita N"],"additional_accession":[]},"is_claimable":false,"name":"Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis.","description":"Disseminated intravascular coagulation (DIC) is one of the major organ dysfunctions associated with sepsis. This retrospective secondary analysis comprised data from a prospective multicenter study to investigate the age-related differences in the survival benefit of anticoagulant therapy in sepsis according to the DIC diagnostic criteria. Adult patients with severe sepsis based on the Sepsis-2 criteria were enrolled and divided into the following groups: (1) anticoagulant group (patients who received anticoagulant therapy) and (2) non-anticoagulant group (patients who did not receive anticoagulant therapy). Patients in the former group were administered antithrombin, recombinant human thrombomodulin, or their combination. The increases in the risk of hospital mortality were suppressed in ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-25T19:44:00.981Z","creation":"2024-11-15T15:29:24.73Z"},"accession":"S-EPMC9166729","cross_references":{"pubmed":["35660774"],"doi":["10.1038/s41598-022-13346-3"]}}