{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["National Natural Science Foundation of China"],"pagination":["9285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9166803"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["This research is to investigate the expression of the TGF-β1/Smads/α-SMA pathway and its effect on bladder histology and function in children with neurogenic bladder (NB). The bladder specimens from 10 children with NB and 8 children with vesicoureteral junction obstruction were collected into the NB and control groups. The expression of TGF-β1, Smad2, Smad3, Smad4, Smad6, α-SMA, fibronectin, collagen I and collagen III in bladder tissues was detected. In addition, the histological characteristics of the bladder were evaluated. A preoperative urodynamic study was performed on all children with NB. We analysed the correlations among the expression of the marker protein a-SMA in myofibroblasts, effector cells of the pathway, and bladder function parameters. Compared with those in the control"],"journal":["Scientific reports"],"pubmed_title":["Activation of the TGF-β1/Smads/α-SMA pathway is related to histological and functional changes in children with neurogenic bladder."],"pmcid":["PMC9166803"],"funding_grant_id":["U1904208"],"pubmed_authors":["Yang X","Pu Q","Wen Y","Lv L","Xu P","Ma Y","Wen JG","Wang J","Liu E","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Activation of the TGF-β1/Smads/α-SMA pathway is related to histological and functional changes in children with neurogenic bladder.","description":"This research is to investigate the expression of the TGF-β1/Smads/α-SMA pathway and its effect on bladder histology and function in children with neurogenic bladder (NB). The bladder specimens from 10 children with NB and 8 children with vesicoureteral junction obstruction were collected into the NB and control groups. The expression of TGF-β1, Smad2, Smad3, Smad4, Smad6, α-SMA, fibronectin, collagen I and collagen III in bladder tissues was detected. In addition, the histological characteristics of the bladder were evaluated. A preoperative urodynamic study was performed on all children with NB. We analysed the correlations among the expression of the marker protein a-SMA in myofibroblasts, effector cells of the pathway, and bladder function parameters. Compared with those in the control","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-25T19:07:55.92Z","creation":"2025-04-06T07:50:11.215Z"},"accession":"S-EPMC9166803","cross_references":{"pubmed":["35662268"],"doi":["10.1038/s41598-022-13470-0"]}}