{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan D"],"funding":["National Institutes of Health","NIH HHS"],"pagination":["e2200311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9167574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(21)"],"pubmed_abstract":["Peripheral nerve mapping tools with higher spatial resolution are needed to advance systems neuroscience, and potentially provide a closed-loop biomarker in neuromodulation applications. Two critical challenges of microscale neural interfaces are 1) how to apply them to small peripheral nerves, and 2) how to minimize chronic reactivity. A flexible microneedle nerve array (MINA) is developed, which is the first high-density penetrating electrode array made with axon-sized silicon microneedles embedded in low-modulus thin silicone. The design, fabrication, acute recording, and chronic reactivity to an implanted MINA, are presented. Distinctive units are identified in the rat peroneal nerve. The authors also demonstrate a long-term, cuff-free, and suture-free fixation manner using rose bengal"],"journal":["Small (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-Dimension, Cuff-Less Microneedle Electrode Array."],"pmcid":["PMC9167574"],"funding_grant_id":["1OT2OD026585","OT2 OD024907","1OT2OD024907","OT2 OD026585"],"pubmed_authors":["Welle EJ","Jiman AA","Chestek CA","Havton LA","Kemp SWP","Bottorff EC","Bruns TM","Seymour JP","Patel PR","Yoon E","Yan D","Ratze DC","Meli D"],"additional_accession":[]},"is_claimable":false,"name":"Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-Dimension, Cuff-Less Microneedle Electrode Array.","description":"Peripheral nerve mapping tools with higher spatial resolution are needed to advance systems neuroscience, and potentially provide a closed-loop biomarker in neuromodulation applications. Two critical challenges of microscale neural interfaces are 1) how to apply them to small peripheral nerves, and 2) how to minimize chronic reactivity. A flexible microneedle nerve array (MINA) is developed, which is the first high-density penetrating electrode array made with axon-sized silicon microneedles embedded in low-modulus thin silicone. The design, fabrication, acute recording, and chronic reactivity to an implanted MINA, are presented. Distinctive units are identified in the rat peroneal nerve. The authors also demonstrate a long-term, cuff-free, and suture-free fixation manner using rose bengal","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-27T04:18:38.818Z","creation":"2025-04-06T19:06:17.716Z"},"accession":"S-EPMC9167574","cross_references":{"pubmed":["35491522"],"doi":["10.1002/smll.202200311"]}}