{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shao H"],"funding":["Program of Yunnan Clinical Research Center for Geriatric Diseases"],"pagination":["7761852"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9168090"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["Currently, there are many effective pharmacological treatments for generalized anxiety disorder (GAD), formulated herbal granule is also an alternative way. Our research intends to construct a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD. Through the TCMSP database, we collected the active ingredients of JWZXF and potential targets of the active ingredients. The GAD-related proteins collected from GeneCards database and DisGeNET database were combined. Component-target protein networks were constructed and visualized using Cytoscape 3.8.2 software to comprehensively clarify the relationships between ingredients, components, and targets. The intersection targets were imported into the STRING database, and the protein-protein intera"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine."],"pmcid":["PMC9168090"],"funding_grant_id":["202105AF150032","202102AA310002"],"pubmed_authors":["Shao H","Gan Q","Chen Z","Zhu Y","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine.","description":"Currently, there are many effective pharmacological treatments for generalized anxiety disorder (GAD), formulated herbal granule is also an alternative way. Our research intends to construct a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD. Through the TCMSP database, we collected the active ingredients of JWZXF and potential targets of the active ingredients. The GAD-related proteins collected from GeneCards database and DisGeNET database were combined. Component-target protein networks were constructed and visualized using Cytoscape 3.8.2 software to comprehensively clarify the relationships between ingredients, components, and targets. The intersection targets were imported into the STRING database, and the protein-protein intera","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-18T12:04:10.805Z","creation":"2025-04-05T20:39:47.91Z"},"accession":"S-EPMC9168090","cross_references":{"pubmed":["35677384"],"doi":["10.1155/2022/7761852"]}}