{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(4)"],"submitter":["Deng W"],"pubmed_abstract":["<h4>Objectives</h4>While co-morbid depression is associated with poor functional outcome among patients with schizophrenia, whether depression similarly predicts poorer outcomes in individuals at clinical high-risk for psychosis (CHR-P) is not clear. The present study aimed to examine depressive symptoms in relation to long-term global functional outcomes in the North American Prodrome Longitudinal Study cohort (NAPLS2).<h4>Methods</h4>CHR individuals were evaluated clinically at baseline and at 12- and 24-month follow-ups for depressive and prodromal symptom severity as well as general functioning. Regression models were built to investigate whether baseline positive and depressive symptom scores predicted longitudinal improvement in global functioning.<h4>Results</h4>A total of 406 CHR i"],"journal":["Psychiatric research and clinical practice"],"pagination":["163-171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9175802"],"repository":["biostudies-literature"],"pubmed_title":["Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis."],"pmcid":["PMC9175802"],"pubmed_authors":["Mathalon DH","Addington J","Bearden CE","Cadenhead KS","Cornblatt BA","Walker EF","Woods SW","Perkins DO","McGlashan TH","Seidman LJ","Cannon T","Tsuang MT","Joormann J","Deng W"],"additional_accession":[]},"is_claimable":false,"name":"Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis.","description":"<h4>Objectives</h4>While co-morbid depression is associated with poor functional outcome among patients with schizophrenia, whether depression similarly predicts poorer outcomes in individuals at clinical high-risk for psychosis (CHR-P) is not clear. The present study aimed to examine depressive symptoms in relation to long-term global functional outcomes in the North American Prodrome Longitudinal Study cohort (NAPLS2).<h4>Methods</h4>CHR individuals were evaluated clinically at baseline and at 12- and 24-month follow-ups for depressive and prodromal symptom severity as well as general functioning. Regression models were built to investigate whether baseline positive and depressive symptom scores predicted longitudinal improvement in global functioning.<h4>Results</h4>A total of 406 CHR i","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-21T14:23:18.441Z","creation":"2025-04-21T14:23:18.441Z"},"accession":"S-EPMC9175802","cross_references":{"pubmed":["36101655"],"doi":["10.1176/appi.prcp.20210023"]}}