{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Mike Slive Foundation for Prostate Cancer Research","U.S. Department of Health & Human Services | NIH | National Cancer Institute","U.S. Department of Defense","NCI NIH HHS"],"pagination":["3186-3196"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9177620"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(23)"],"pubmed_abstract":["For human prostate cancer, the chromosome 8p21 locus, which contains NKX3.1 and the microRNA (miR)-3622 family (miR-3622a/b), is a frequently deleted region. Thus, miR-3622 is proposed as a suppressor for prostate cancer, but its role remains debatable. In the present study, we found that expression of miR-3622a was lower, whereas expression of miR-3622b-3p was higher in human prostate cancer tissues than in normal prostate tissues. miR-3622a-3p inhibited cell migration and invasion of human prostate cancer cells, whereas miR-3622b-3p facilitated cell proliferation, migration, and invasion. To address the opposing roles of miR-3622 family members in various human prostate cancer cell lines, we knocked out (KO) endogenous miR-3622, including both miR-3622a/b. Our results showed that miR-362"],"journal":["Oncogene"],"pubmed_title":["The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression."],"pmcid":["PMC9177620"],"funding_grant_id":["W81XWH-21-1-0100","U54 CA118623","U54 CA118948","U54 CA118638","P30 CA013148","W81XWH-20-1-0426","CA118948"],"pubmed_authors":["Hu F","Liu Z","Zhang Y","Bae S","Wei S","Liu R","Zhang C","Xu Z","Wen W","Li M","Zhou J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.","description":"For human prostate cancer, the chromosome 8p21 locus, which contains NKX3.1 and the microRNA (miR)-3622 family (miR-3622a/b), is a frequently deleted region. Thus, miR-3622 is proposed as a suppressor for prostate cancer, but its role remains debatable. In the present study, we found that expression of miR-3622a was lower, whereas expression of miR-3622b-3p was higher in human prostate cancer tissues than in normal prostate tissues. miR-3622a-3p inhibited cell migration and invasion of human prostate cancer cells, whereas miR-3622b-3p facilitated cell proliferation, migration, and invasion. To address the opposing roles of miR-3622 family members in various human prostate cancer cell lines, we knocked out (KO) endogenous miR-3622, including both miR-3622a/b. Our results showed that miR-362","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-19T22:46:31.713Z","creation":"2025-04-19T22:46:31.713Z"},"accession":"S-EPMC9177620","cross_references":{"pubmed":["35501464"],"doi":["10.1038/s41388-022-02289-8"]}}