{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Wu W"],"pubmed_abstract":["Increasing evidence supports the notion that filamentous actin (F-actin) and globular actin exist in the nuclei of somatic cells, and are involved in chromatin remodeling, gene transcription regulation and DNA damage repair. However, the underlying mechanisms of how nuclear F-actin are polymerized in cells remain incompletely understood. Here, we identify potential kinase targets that participate in nuclear F-actin polymerization in ovarian cancer cells using small-molecule inhibitor library screening in combination with a deep learning approach. The analysis of the targets of the inhibitors used in this study suggest that the PI3K-AKT pathway are involved in regulating nuclear F-actin organization in ovarian cancer cells. Our work lays the foundation for uncovering the important roles of "],"journal":["Frontiers in cell and developmental biology"],"pagination":["869531"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9178185"],"repository":["biostudies-literature"],"pubmed_title":["Investigation of the Potential Mechanisms Underlying Nuclear F-Actin Organization in Ovarian Cancer Cells by High-Throughput Screening in Combination With Deep Learning."],"pmcid":["PMC9178185"],"pubmed_authors":["Wang M","Zheng Y","Wietek N","Xing X","Feng Y","Chong K","Ahmed AA","Wu W","El-Sahhar S","Zang R"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of the Potential Mechanisms Underlying Nuclear F-Actin Organization in Ovarian Cancer Cells by High-Throughput Screening in Combination With Deep Learning.","description":"Increasing evidence supports the notion that filamentous actin (F-actin) and globular actin exist in the nuclei of somatic cells, and are involved in chromatin remodeling, gene transcription regulation and DNA damage repair. However, the underlying mechanisms of how nuclear F-actin are polymerized in cells remain incompletely understood. Here, we identify potential kinase targets that participate in nuclear F-actin polymerization in ovarian cancer cells using small-molecule inhibitor library screening in combination with a deep learning approach. The analysis of the targets of the inhibitors used in this study suggest that the PI3K-AKT pathway are involved in regulating nuclear F-actin organization in ovarian cancer cells. Our work lays the foundation for uncovering the important roles of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T11:54:57.273Z","creation":"2024-11-07T02:50:01.004Z"},"accession":"S-EPMC9178185","cross_references":{"pubmed":["35693931"],"doi":["10.3389/fcell.2022.869531"]}}