biostudies-literatureUnknown95Dinh H<h4>Introduction and importance</h4> Autosomal recessive osteopetrosis (ARO) is a group of disease characterized by osteoclast dysfunction inhibiting bone resorption and bone turnover, with TCIRG1-associated ARO leading to autosomal recessive infantile malignant osteopetrosis (OPTB1, MIM entry number # 259700). While most patients with TCIRG1-associated osteopetrosis present a malignant clinical course and shortened lifespan, a few cases of mild osteopetrosis associated with TCIRG1 have been reported recently. In this study we report a rare case of non-malignant TCIRG1-associated osteopetrosis, with detail clinical characterization, genetic analysis and underwent successful total hip replacement surgery. <h4>Case presentation</h4> 24-year-old female patient came to us with limp gait, hip pInternational journal of surgery case reportshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9178469biostudies-literatureSuccessful total hip arthroplasty for patient with TCIRG1-associated autosomal recessive osteopetrosisPMC9178469Dinh HTran TNguyen TMinh TLuong LTrung TfalseSuccessful total hip arthroplasty for patient with TCIRG1-associated autosomal recessive osteopetrosis<h4>Introduction and importance</h4> Autosomal recessive osteopetrosis (ARO) is a group of disease characterized by osteoclast dysfunction inhibiting bone resorption and bone turnover, with TCIRG1-associated ARO leading to autosomal recessive infantile malignant osteopetrosis (OPTB1, MIM entry number # 259700). While most patients with TCIRG1-associated osteopetrosis present a malignant clinical course and shortened lifespan, a few cases of mild osteopetrosis associated with TCIRG1 have been reported recently. In this study we report a rare case of non-malignant TCIRG1-associated osteopetrosis, with detail clinical characterization, genetic analysis and underwent successful total hip replacement surgery. <h4>Case presentation</h4> 24-year-old female patient came to us with limp gait, hip p2022-01-01T00:00:00Z2022 Jun2025-04-22T08:50:36.128Z2025-04-05T22:40:47.386ZS-EPMC9178469