biostudies-literatureChen YNational Natural Science Foundation of ChinaNCI NIH HHSNational Institutes of HealthNIH HHSCancer Prevention and Research Institute of Texas5925https://www.ebi.ac.uk/biostudies/studies/S-EPMC9180643biostudies-literatureUnknown23(11)Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein-protein interactions, or endocytosis of the substrate. In doing so, monoubiquitination is implicated in diverse cellular processes, including gene transcription, endocytosis, signal transduction, cell death, and DNA damage repair, which in turn regulate cell-cycle progression, survival, proliferation, and stress response. In this review, we summarize the functions of monoubiquitination and discuss how this PTM modulates homeostasis and cancer.International journal of molecular sciencesMonoubiquitination in Homeostasis and Cancer.PMC9180643RP19002931900935R01 CA166051R01CA166051Yao YMa LZhou DChen YSun YYao FfalseMonoubiquitination in Homeostasis and Cancer.Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein-protein interactions, or endocytosis of the substrate. In doing so, monoubiquitination is implicated in diverse cellular processes, including gene transcription, endocytosis, signal transduction, cell death, and DNA damage repair, which in turn regulate cell-cycle progression, survival, proliferation, and stress response. In this review, we summarize the functions of monoubiquitination and discuss how this PTM modulates homeostasis and cancer.2022-01-01T00:00:00Z2022 May2025-04-21T14:49:27.717Z2024-11-08T20:06:40.406ZS-EPMC91806433568260510.3390/ijms23115925