{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zenkel M"],"funding":["The Glaucoma Foundation New York (The Barry Friedberg and Charlotte Moss Family Foundation)","Deutsche Forschungsgemeinschaft","The Glaucoma Foundation New York"],"pagination":["5977"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9180992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(11)"],"pubmed_abstract":["Pseudoexfoliation (PEX) syndrome, a stress-induced fibrotic matrix process, is the most common recognizable cause of open-angle glaucoma worldwide. The recent identification of PEX-associated gene variants uncovered the vitamin A metabolic pathway as a factor influencing the risk of disease. In this study, we analyzed the role of the retinoic acid (RA) signaling pathway in the PEX-associated matrix metabolism and evaluated its targeting as a potential candidate for an anti-fibrotic intervention. We provided evidence that decreased expression levels of RA pathway components and diminished RA signaling activity occur in an antagonistic crosstalk with TGF-β1/Smad signaling in ocular tissues and cells from PEX patients when compared with age-matched controls. Genetic and pharmacologic modes of"],"journal":["International journal of molecular sciences"],"pubmed_title":["Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome."],"pmcid":["PMC9180992"],"funding_grant_id":["SCHL 366/11-1; PA 2353/4-1","N.A.","SCHL 366/11-1","PA 2353/4-1"],"pubmed_authors":["Weller JM","Schlotzer-Schrehardt U","Pasutto F","Konig L","Hohberger B","Gießl A","Hubner L","Ostermann TA","Kruse FE","Gusek-Schneider GC","Hoja U","Berner D","Zenkel M"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome.","description":"Pseudoexfoliation (PEX) syndrome, a stress-induced fibrotic matrix process, is the most common recognizable cause of open-angle glaucoma worldwide. The recent identification of PEX-associated gene variants uncovered the vitamin A metabolic pathway as a factor influencing the risk of disease. In this study, we analyzed the role of the retinoic acid (RA) signaling pathway in the PEX-associated matrix metabolism and evaluated its targeting as a potential candidate for an anti-fibrotic intervention. We provided evidence that decreased expression levels of RA pathway components and diminished RA signaling activity occur in an antagonistic crosstalk with TGF-β1/Smad signaling in ocular tissues and cells from PEX patients when compared with age-matched controls. Genetic and pharmacologic modes of","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-25T19:02:00.544Z","creation":"2025-02-19T04:56:41.845Z"},"accession":"S-EPMC9180992","cross_references":{"pubmed":["35682657"],"doi":["10.3390/ijms23115977"]}}