biostudies-literatureZhou GAgricultural Science and Technology Innovation Fund Project of Hunan ProvinceChangsha Municipal Natural Science FoundationNational Natural Science Foundation of China6173https://www.ebi.ac.uk/biostudies/studies/S-EPMC9181463biostudies-literatureUnknown23(11)The hollow trait is crucial for commercial quality of cucumber (<i>Cucumis sativus</i> L.) fruit, and its molecular regulatory mechanism is poorly understood due to its environmental sensitivity. In the previous research, we obtained the hollow and the non-hollow materials of ecotype cucumbers of South China, which were not easily affected by the external environment through a systematic breeding method. In this study, first, we proposed to use the percentage of the hollow area as the criterion to compare the hollow characteristics between two materials, and to analyze the formation mechanism of early hollow trait from the perspective of cytology. The results showed that the hollow trait occurred in the early stage of fruit development, and formed with the opening of carpel ventral zipped International journal of molecular sciencesThe Formation of Hollow Trait in Cucumber (<i>Cucumis sativus</i> L.) Fruit Is Controlled by <i>CsALMT2</i>.PMC9181463kq2014169321725852021CX27Liu XYang KLu XWang CTian YZhou GChen HChen CfalseThe Formation of Hollow Trait in Cucumber (<i>Cucumis sativus</i> L.) Fruit Is Controlled by <i>CsALMT2</i>.The hollow trait is crucial for commercial quality of cucumber (<i>Cucumis sativus</i> L.) fruit, and its molecular regulatory mechanism is poorly understood due to its environmental sensitivity. In the previous research, we obtained the hollow and the non-hollow materials of ecotype cucumbers of South China, which were not easily affected by the external environment through a systematic breeding method. In this study, first, we proposed to use the percentage of the hollow area as the criterion to compare the hollow characteristics between two materials, and to analyze the formation mechanism of early hollow trait from the perspective of cytology. The results showed that the hollow trait occurred in the early stage of fruit development, and formed with the opening of carpel ventral zipped 2022-01-01T00:00:00Z2022 May2025-04-25T20:25:44.293Z2025-02-19T03:52:16.59ZS-EPMC91814633568285810.3390/ijms23116173