{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(6)"],"submitter":["Alsaaod M"],"funding":["Heard Health Management Initiator Grant, Institute of Animal Pathology and Clinic for Ruminants","Streuli Tiergesundheit AG"],"pubmed_abstract":["The efficacy of salicylic acid paste (SA) in the treatment of ulcerative bovine digital dermatitis (BDD) was assessed by combining clinical and histopathological analyses with molecular biological techniques. The latter were conducted in a blinded manner to reach maximum objectivity. Prior to treatment, M2-stage BDD lesions (n = 26, diagnosed in 21 dairy cows) exhibited ulceration, with severe perivascular, chronic, lymphoplasmacytic dermatitis and extensive keratinolysis being noted in most cases. Pretreatment biopsy samples (n = 12) followed by povidone-iodine ointment under bandage for one week before administration of SA paste were tested positive for Treponema spp. by blinded PCR and fluorescent in situ hybridization (FISH). Subsequent treatment consisted of application of SA and band"],"journal":["PloS one"],"pagination":["e0269521"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9182225"],"repository":["biostudies-literature"],"pubmed_title":["Proof of an optimized salicylic acid paste-based treatment concept of ulcerative M2-stage digital dermatitis lesions in 21 dairy cows."],"pmcid":["PMC9182225"],"pubmed_authors":["Miglinci L","Gurtner C","Jensen TK","Alsaaod M","Brandt S","Pluss J","Studer E","Steiner A"],"additional_accession":[]},"is_claimable":false,"name":"Proof of an optimized salicylic acid paste-based treatment concept of ulcerative M2-stage digital dermatitis lesions in 21 dairy cows.","description":"The efficacy of salicylic acid paste (SA) in the treatment of ulcerative bovine digital dermatitis (BDD) was assessed by combining clinical and histopathological analyses with molecular biological techniques. The latter were conducted in a blinded manner to reach maximum objectivity. Prior to treatment, M2-stage BDD lesions (n = 26, diagnosed in 21 dairy cows) exhibited ulceration, with severe perivascular, chronic, lymphoplasmacytic dermatitis and extensive keratinolysis being noted in most cases. Pretreatment biopsy samples (n = 12) followed by povidone-iodine ointment under bandage for one week before administration of SA paste were tested positive for Treponema spp. by blinded PCR and fluorescent in situ hybridization (FISH). Subsequent treatment consisted of application of SA and band","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-03T17:30:51.085Z","creation":"2025-05-18T13:23:11.983Z"},"accession":"S-EPMC9182225","cross_references":{"pubmed":["35679311"],"doi":["10.1371/journal.pone.0269521"]}}