biostudies-literatureLee SKorea Environmental Industry and Technology Institute2220https://www.ebi.ac.uk/biostudies/studies/S-EPMC9182653biostudies-literatureUnknown14(11)The increased use of plastics has led to severe environmental pollution, particularly by microplastics-plastic particles 5 mm or less in diameter. These particles are formed by environmental factors such as weathering and ultraviolet irradiation, thereby making environmental pollution worse. This environmental pollution intensifies human exposure to microplastics via food chains. Despite potential negative effects, few toxicity assessments on microplastics are available. In this study, two sizes of polytetrafluoroethylene (PTFE) microplastics, approximately 5 μm and 10-50 μm, were manufactured and used for single and four-week repeated toxicity and pharmacokinetic studies. Toxicological effects were comprehensively evaluated with clinical signs, body weight, food and water consumption, necPolymersIn Vivo Toxicity and Pharmacokinetics of Polytetrafluoroethylene Microplastics in ICR Mice.PMC91826532020003120002Lee SLee KRSeong KYKang KKKang SLee JKim KChoi JHYang SYSeo MSSung SESung MfalseIn Vivo Toxicity and Pharmacokinetics of Polytetrafluoroethylene Microplastics in ICR Mice.The increased use of plastics has led to severe environmental pollution, particularly by microplastics-plastic particles 5 mm or less in diameter. These particles are formed by environmental factors such as weathering and ultraviolet irradiation, thereby making environmental pollution worse. This environmental pollution intensifies human exposure to microplastics via food chains. Despite potential negative effects, few toxicity assessments on microplastics are available. In this study, two sizes of polytetrafluoroethylene (PTFE) microplastics, approximately 5 μm and 10-50 μm, were manufactured and used for single and four-week repeated toxicity and pharmacokinetic studies. Toxicological effects were comprehensively evaluated with clinical signs, body weight, food and water consumption, nec2022-01-01T00:00:00Z2022 May2025-05-29T21:21:11.076Z2025-05-29T21:21:11.076ZS-EPMC91826533568389610.3390/polym14112220