biostudies-literatureRen QBai-Qian-Wan Engineering and Technology Master ProjectNational Natural Science Foundation of China2255https://www.ebi.ac.uk/biostudies/studies/S-EPMC9183142biostudies-literatureUnknown14(11)This systematic review aimed to examine differences in growth outcomes between breastfed infants and infants fed with formula with different protein/energy ratios during the first six months of life. We conducted a systematic review in the PubMed, Web of Science, and Springer databases. Twenty clinical trials qualified for inclusion. We extracted data about the growth outcomes of infants who were exclusive breastfed or exclusively infant formula fed in the first six months and used a meta-analysis to pool the finding data. We categorized study formulas into four groups according to their protein content: <1.8, 1.8-2.0, 2.1-2.2, and >2.2 g/100 kcal. In the first month of life, growth was not different between formula- and breastfed infants. During 2-3 months of life, growth was fasterNutrientsThe Association of Formula Protein Content and Growth in Early Infancy: A Systematic Review and Meta-Analysis.PMC9183142No. 821735002019ZX07B01Zhang WLyu YZheng CYe WJiang SLi KSun HZhou YShi HRen QXu YfalseThe Association of Formula Protein Content and Growth in Early Infancy: A Systematic Review and Meta-Analysis.This systematic review aimed to examine differences in growth outcomes between breastfed infants and infants fed with formula with different protein/energy ratios during the first six months of life. We conducted a systematic review in the PubMed, Web of Science, and Springer databases. Twenty clinical trials qualified for inclusion. We extracted data about the growth outcomes of infants who were exclusive breastfed or exclusively infant formula fed in the first six months and used a meta-analysis to pool the finding data. We categorized study formulas into four groups according to their protein content: <1.8, 1.8-2.0, 2.1-2.2, and >2.2 g/100 kcal. In the first month of life, growth was not different between formula- and breastfed infants. During 2-3 months of life, growth was faster2022-01-01T00:00:00Z2022 May2025-04-19T08:40:15.201Z2024-12-04T10:06:44.622ZS-EPMC91831423568405510.3390/nu14112255