{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jarr KU"],"funding":["NHLBI NIH HHS"],"pagination":["e145-e154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9183217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(6)"],"pubmed_abstract":["A key feature of atherogenesis is the accumulation of diseased and dying cells within the lesional necrotic core. While the burden of intraplaque apoptotic cells may be driven in part by an increase in programmed cell death, mounting evidence suggests that their presence may primarily be dictated by a defect in programmed cell removal, or efferocytosis. In this brief review, we will summarize the evidence suggesting that inflammation-dependent changes within the plaque render target cells inedible and reduce the appetite of lesional phagocytes. We will present the genetic causation studies, which indicate these phenomena promote lesion expansion and plaque vulnerability, and the interventional data which suggest that these processes can be reversed. Particular emphasis is provided related "],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis."],"pmcid":["PMC9183217"],"funding_grant_id":["R35 HL144475"],"pubmed_authors":["Leeper NJ","Weissman IL","Kojima Y","Jarr KU"],"additional_accession":[]},"is_claimable":false,"name":"2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis.","description":"A key feature of atherogenesis is the accumulation of diseased and dying cells within the lesional necrotic core. While the burden of intraplaque apoptotic cells may be driven in part by an increase in programmed cell death, mounting evidence suggests that their presence may primarily be dictated by a defect in programmed cell removal, or efferocytosis. In this brief review, we will summarize the evidence suggesting that inflammation-dependent changes within the plaque render target cells inedible and reduce the appetite of lesional phagocytes. We will present the genetic causation studies, which indicate these phenomena promote lesion expansion and plaque vulnerability, and the interventional data which suggest that these processes can be reversed. Particular emphasis is provided related ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-21T13:39:11.041Z","creation":"2025-04-21T13:39:11.041Z"},"accession":"S-EPMC9183217","cross_references":{"pubmed":["35387480"],"doi":["10.1161/ATVBAHA.122.317049","10.1161/atvbaha.122.317049"]}}