{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arvind A"],"funding":["NCI NIH HHS","National Institutes of Health"],"pagination":["1091-1093.e3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9184301"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(4)"],"pubmed_abstract":["Early hepatocellular cancer (HCC) detection is associated with curative treatment and improved survival.<sup>1</sup> The American Association for the Study of Liver Diseases recommends semiannual ultrasound and α-fetoprotein (AFP) in patients with cirrhosis, and those with abnormal results should undergo diagnostic multiphase computed tomography (CT) or magnetic resonance imaging (MRI).<sup>2</sup> The Liver Imaging Reporting and Data System (LI-RADS) was devised to standardize reporting of liver observations in at-risk individuals, ranging from LR-1 (\"definitely benign\") to LR-5 (\"definitely HCC''), with indeterminate observations classified as LR-3 (\"intermediate probability of malignancy\").<sup>3</sup> A study among 999 cirrhosis patients found that indeterminate liver observations are "],"journal":["Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association"],"pubmed_title":["Risk of Hepatocellular Carcinoma in Patients With Indeterminate (LI-RADS 3) Liver Observations."],"pmcid":["PMC9184301"],"funding_grant_id":["R01 CA255621","R01 CA212008","R01 CA233794","U01 CA230694"],"pubmed_authors":["Browning T","Zaki T","Yokoo T","Manwaring C","Singal AG","Yekkaluri S","Parikh ND","Zhu H","North American Liver Cancer (NALC) Consortium","Marrero JA","Khatri G","Arvind A","Rich NE","Fetzer D","Burkholder D","Joshi S","Yopp AC","Hoshida Y","Gopal P"],"additional_accession":[]},"is_claimable":false,"name":"Risk of Hepatocellular Carcinoma in Patients With Indeterminate (LI-RADS 3) Liver Observations.","description":"Early hepatocellular cancer (HCC) detection is associated with curative treatment and improved survival.<sup>1</sup> The American Association for the Study of Liver Diseases recommends semiannual ultrasound and α-fetoprotein (AFP) in patients with cirrhosis, and those with abnormal results should undergo diagnostic multiphase computed tomography (CT) or magnetic resonance imaging (MRI).<sup>2</sup> The Liver Imaging Reporting and Data System (LI-RADS) was devised to standardize reporting of liver observations in at-risk individuals, ranging from LR-1 (\"definitely benign\") to LR-5 (\"definitely HCC''), with indeterminate observations classified as LR-3 (\"intermediate probability of malignancy\").<sup>3</sup> A study among 999 cirrhosis patients found that indeterminate liver observations are ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-04-08T23:10:07.376Z","creation":"2026-04-07T13:17:43.443Z"},"accession":"S-EPMC9184301","cross_references":{"pubmed":["34902571"],"doi":["10.1016/j.cgh.2021.11.042"]}}