{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee KK"],"funding":["British Heart Foundation","Medical Research Council","Chief Scientist Office"],"pagination":["e068424"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9189738"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["377"],"pubmed_abstract":["<h4>Objectives</h4>To evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with clinical characteristics.<h4>Design</h4>Individual patient level data meta-analysis and modelling study.<h4>Setting</h4>Fourteen studies from 13 countries, including randomised controlled trials and prospective observational studies.<h4>Participants</h4>Individual patient level data for 10 369 patients with suspected acute heart failure were pooled for the meta-analysis to evaluate NT-proBNP thresholds. A decision support tool (Collaboration for the Diagnosis and Evaluation of Heart Failure (CoDE-HF)) that combines NT-proBNP with clinical variables"],"journal":["BMJ (Clinical research ed.)"],"pubmed_title":["Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study."],"pmcid":["PMC9189738"],"funding_grant_id":["CGA/19/01"],"pubmed_authors":["Mesquita ET","Wiemer JC","Bahrmann P","Pinto Y","Anwar M","Hollander J","Doudesis D","van Kimmenade RRJ","Chenevier-Gobeaux C","Gargani L","Behnes M","Richards AM","Gegenhuber A","Ibrahim I","McMurray JJV","Yoshimura M","Freedman B","Wussler D","Mueller C","Mockel M","Collins SP","Claessens YE","Bayes-Genis A","Moe G","Fernando C","Mueller T","Japp AG","van den Meiracker AH","Singer A","Pemberton C","deFilippi C","Lindsell CJ","Hanon O","Vidal JS","Tsanas A","Januzzi JL","Bombelli M","Strebel I","CoDE-HF investigators","Seliger S","Jourdain P","Akin I","Rutten JHW","Mills NL","Albano G","Chung T","Nazerian P","Sabti Z","Astengo F","Gaggin HK","Grassi G","Newby DE","Coste J","Pugliese NR","Shah ASV","Lam L","Lee KK","Villacorta H","Komukai K","Cameron P","Kozhuharov N","Neumaier M"],"additional_accession":[]},"is_claimable":false,"name":"Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study.","description":"<h4>Objectives</h4>To evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with clinical characteristics.<h4>Design</h4>Individual patient level data meta-analysis and modelling study.<h4>Setting</h4>Fourteen studies from 13 countries, including randomised controlled trials and prospective observational studies.<h4>Participants</h4>Individual patient level data for 10 369 patients with suspected acute heart failure were pooled for the meta-analysis to evaluate NT-proBNP thresholds. A decision support tool (Collaboration for the Diagnosis and Evaluation of Heart Failure (CoDE-HF)) that combines NT-proBNP with clinical variables","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-05T13:29:17.287Z","creation":"2024-11-20T23:15:10.03Z"},"accession":"S-EPMC9189738","cross_references":{"pubmed":["35697365"],"doi":["10.1136/bmj-2021-068424"]}}