biostudies-literatureLee KKBritish Heart FoundationMedical Research CouncilChief Scientist Officee068424https://www.ebi.ac.uk/biostudies/studies/S-EPMC9189738biostudies-literatureUnknown377<h4>Objectives</h4>To evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with clinical characteristics.<h4>Design</h4>Individual patient level data meta-analysis and modelling study.<h4>Setting</h4>Fourteen studies from 13 countries, including randomised controlled trials and prospective observational studies.<h4>Participants</h4>Individual patient level data for 10 369 patients with suspected acute heart failure were pooled for the meta-analysis to evaluate NT-proBNP thresholds. A decision support tool (Collaboration for the Diagnosis and Evaluation of Heart Failure (CoDE-HF)) that combines NT-proBNP with clinical variablesBMJ (Clinical research ed.)Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study.PMC9189738CGA/19/01Mesquita ETWiemer JCBahrmann PPinto YAnwar MHollander JDoudesis Dvan Kimmenade RRJChenevier-Gobeaux CGargani LBehnes MRichards AMGegenhuber AIbrahim IMcMurray JJVYoshimura MFreedman BWussler DMueller CMockel MCollins SPClaessens YEBayes-Genis AMoe GFernando CMueller TJapp AGvan den Meiracker AHSinger APemberton CdeFilippi CLindsell CJHanon OVidal JSTsanas AJanuzzi JLBombelli MStrebel ICoDE-HF investigatorsSeliger SJourdain PAkin IRutten JHWMills NLAlbano GChung TNazerian PSabti ZAstengo FGaggin HKGrassi GNewby DECoste JPugliese NRShah ASVLam LLee KKVillacorta HKomukai KCameron PKozhuharov NNeumaier MfalseDevelopment and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study.<h4>Objectives</h4>To evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with clinical characteristics.<h4>Design</h4>Individual patient level data meta-analysis and modelling study.<h4>Setting</h4>Fourteen studies from 13 countries, including randomised controlled trials and prospective observational studies.<h4>Participants</h4>Individual patient level data for 10 369 patients with suspected acute heart failure were pooled for the meta-analysis to evaluate NT-proBNP thresholds. A decision support tool (Collaboration for the Diagnosis and Evaluation of Heart Failure (CoDE-HF)) that combines NT-proBNP with clinical variables2022-01-01T00:00:00Z2022 Jun2025-04-05T13:29:17.287Z2024-11-20T23:15:10.03ZS-EPMC91897383569736510.1136/bmj-2021-068424