{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carter AR"],"funding":["UK Medical Research Council Integrative Epidemiology Unit","British Heart Foundation","University of Bristol","Medical Research Council","UK Medical Research Council and University of Bristol","British Heart Foundation Centre of Research Excellence","Imperial College London and a National Institute for Health Research Clinical Lectureship","British Heart Foundation University of Bristol Accelerator Award"],"pagination":["885-897"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9189971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(3)"],"pubmed_abstract":["<h4>Background</h4>Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease.<h4>Methods</h4>In up to 320 120 UK Biobank participants of White British ancestry (mean age = 57 years, female 54%), we created polygenic scores for nine cardiovascular risk factors or diseases: alcohol consumption, body mass index, low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes and stroke. We estimated whether educational attainment modified genetic susceptibility to these risk factors and diseases.<h4>Results</h4>On the additive scale, higher educational attainmen"],"journal":["International journal of epidemiology"],"pubmed_title":["Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank."],"pmcid":["PMC9189971"],"funding_grant_id":["1837149","CL-2020–16-0011","MC_UU_00011/1","MR/M020894/1","AA/18/7/34219","RE/18/4/34215","MC_UU_00011/6"],"pubmed_authors":["Harrison S","Carter AR","Gill D","Davey Smith G","Taylor AE","Howe LD","Davies NM"],"additional_accession":[]},"is_claimable":false,"name":"Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.","description":"<h4>Background</h4>Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease.<h4>Methods</h4>In up to 320 120 UK Biobank participants of White British ancestry (mean age = 57 years, female 54%), we created polygenic scores for nine cardiovascular risk factors or diseases: alcohol consumption, body mass index, low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes and stroke. We estimated whether educational attainment modified genetic susceptibility to these risk factors and diseases.<h4>Results</h4>On the additive scale, higher educational attainmen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T19:13:00.153Z","creation":"2025-02-19T01:34:50.449Z"},"accession":"S-EPMC9189971","cross_references":{"pubmed":["35134953"],"doi":["10.1093/ije/dyac002"]}}