biostudies-literatureCarter ARUK Medical Research Council Integrative Epidemiology UnitBritish Heart FoundationUniversity of BristolMedical Research CouncilUK Medical Research Council and University of BristolBritish Heart Foundation Centre of Research ExcellenceImperial College London and a National Institute for Health Research Clinical LectureshipBritish Heart Foundation University of Bristol Accelerator Award885-897https://www.ebi.ac.uk/biostudies/studies/S-EPMC9189971biostudies-literatureUnknown51(3)<h4>Background</h4>Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease.<h4>Methods</h4>In up to 320 120 UK Biobank participants of White British ancestry (mean age = 57 years, female 54%), we created polygenic scores for nine cardiovascular risk factors or diseases: alcohol consumption, body mass index, low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes and stroke. We estimated whether educational attainment modified genetic susceptibility to these risk factors and diseases.<h4>Results</h4>On the additive scale, higher educational attainmenInternational journal of epidemiologyEducational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.PMC91899711837149CL-2020–16-0011MC_UU_00011/1MR/M020894/1AA/18/7/34219RE/18/4/34215MC_UU_00011/6Harrison SCarter ARGill DDavey Smith GTaylor AEHowe LDDavies NMfalseEducational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.<h4>Background</h4>Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease.<h4>Methods</h4>In up to 320 120 UK Biobank participants of White British ancestry (mean age = 57 years, female 54%), we created polygenic scores for nine cardiovascular risk factors or diseases: alcohol consumption, body mass index, low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes and stroke. We estimated whether educational attainment modified genetic susceptibility to these risk factors and diseases.<h4>Results</h4>On the additive scale, higher educational attainmen2022-01-01T00:00:00Z2022 Jun2025-04-04T19:13:00.153Z2025-02-19T01:34:50.449ZS-EPMC91899713513495310.1093/ije/dyac002