biostudies-literatureScaravilli VMinistero dell'Università e della RicercaMinistero dell&apos;Università e della Ricerca176https://www.ebi.ac.uk/biostudies/studies/S-EPMC9191402biostudies-literatureUnknown26(1)<h4>Objective</h4>To assess the impact of treatment with steroids on the incidence and outcome of ventilator-associated pneumonia (VAP) in mechanically ventilated COVID-19 patients.<h4>Design</h4>Propensity-matched retrospective cohort study from February 24 to December 31, 2020, in 4 dedicated COVID-19 Intensive Care Units (ICU) in Lombardy (Italy).<h4>Patients</h4>Adult consecutive mechanically ventilated COVID-19 patients were subdivided into two groups: (1) treated with low-dose corticosteroids (dexamethasone 6 mg/day intravenous for 10 days) (DEXA+); (2) not treated with corticosteroids (DEXA-). A propensity score matching procedure (1:1 ratio) identified patients' cohorts based on: age, weight, PEEP Level, PaO₂/FiO₂ ratio, non-respiratory Sequential Organ FailurCritical care (London, England)Impact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study.PMC9191402Ricerca Finalizzata project COVID-2020-12371675 &quot;COVID19: EPIDEMIOLOGICAL, CLINICAL, GENETIC, AND SOCIAL DETERMINANTS OF INFECTION AND DISEASE PROGRESSION&quot;Ricerca Finalizzata project COVID-2020-12371675 "COVID19: EPIDEMIOLOGICAL, CLINICAL, GENETIC, AND SOCIAL DETERMINANTS OF INFECTION AND DISEASE PROGRESSION"Grasselli GBellani GGreco MScaravilli VMonti GGuzzardella ABeltrama VMuscatello ABandera APesenti AMadotto FfalseImpact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study.<h4>Objective</h4>To assess the impact of treatment with steroids on the incidence and outcome of ventilator-associated pneumonia (VAP) in mechanically ventilated COVID-19 patients.<h4>Design</h4>Propensity-matched retrospective cohort study from February 24 to December 31, 2020, in 4 dedicated COVID-19 Intensive Care Units (ICU) in Lombardy (Italy).<h4>Patients</h4>Adult consecutive mechanically ventilated COVID-19 patients were subdivided into two groups: (1) treated with low-dose corticosteroids (dexamethasone 6 mg/day intravenous for 10 days) (DEXA+); (2) not treated with corticosteroids (DEXA-). A propensity score matching procedure (1:1 ratio) identified patients' cohorts based on: age, weight, PEEP Level, PaO₂/FiO₂ ratio, non-respiratory Sequential Organ Failur2022-01-01T00:00:00Z2022 Jun2026-05-29T01:05:12.79Z2025-04-05T20:40:26.189ZS-EPMC91914023569815510.1186/s13054-022-04049-2