{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Castilho JL"],"funding":["NCATS NIH HHS","NIDA NIH HHS","NIA NIH HHS","NCRR NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","NIAAA NIH HHS","National Institutes of Health","NEI NIH HHS","NIMHD NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["854-862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9194634"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(6)"],"pubmed_abstract":["<h4>Background</h4>Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH) is associated with deleterious immune senescence, activation, and inflammation, which may contribute to carcinogenesis and excess cancer risk. We examined whether low CD4/CD8 ratios predicted cancer among PWH in the United States and Canada.<h4>Methods</h4>We examined all cancer-free PWH with 1 or more CD4/CD8 values from North American AIDS Cohort Collaboration on Research and Design observational cohorts with validated cancer diagnoses between 1998 and 2016. We evaluated the association between time-lagged CD4/CD8 ratio and risk of specific cancers in multivariable, time-updated Cox proportional hazard models using restricted cubic spines. Models were adjusted for age, sex, race and ethnicity, "],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["CD4/CD8 Ratio and Cancer Risk Among Adults With HIV."],"pmcid":["PMC9194634"],"funding_grant_id":["K01 AI131895","K24 DA000432","UL1 TR002378","K23EY013707","U01 AI038858","U01 AI038855","P30MH62246","R24AI067039","U01 HL146242","R01 AA016893","U01 HL146241","U01 HL146240","U01AI038855","U01 HL146245","U01AI038858","U01AI069918","UL1 TR000083","F31DA037788","K07 CA225404","P30CA068485-23S3","K23 EY013707","P30 AI027767","P30 AI027763","F31 AI124794","UL1 TR000004","P30 CA068485","U54 AG062334","N02CP055504","K23AI120875","G12MD007583","U01 HL146194","U01 HL146193","U01 HL146192","R01DA012568","K01 AI093197","R34DA045592","KL2TR000421","P30 AI027757","F31AI124794","U10EY008052","F31 DA037788","G12 MD007583","U24AA020794","U01DA036935","N01CP01004","P30 AI094189","R24 AI067039","K24 AI065298","U01AI069432","U01 DA036297","K01AI131895","R01 DA012568","N02CP91027","U01HL146205","U01HL146204","U01HL146203","U01HL146202","U01HL146201","U01 AI069918","P30AI094189","U01AA013566","K24AI065298","K24 AI118591","UM1 AI068634","U01 HL146205","U01 HL146204","KL2 TR000421","U01 HL146203","U01HL146208","R01 DA011602","U01 HL146208","U01 AI068636","U01 AA020790","N02 CP055504","U01 HL146202","U10EY008067","U01HL146333","U01 HL146201","K24AI118591","K07CA225404","U01AI069434","U01 AI068634","U10 EY008067","U54 GM133807","R01AA016893","P30 AI036219","U24 AA020794","K23 AI120875","P30AI036219","K01 AI162247","U10EY008057","U01AI068636","U01AA020790","UM1 AI069432","U01AI068634","P30 AI050410","U10 EY008057","U01 AA013566","P30 AI110527","U01DA03629","P01 AA029545","K24DA000432","P30AI050409","U10 EY008052","L30 AI133812","R34 DA045592","P30AI050410","P30AI110527","U01HL146194","P30AI027757","UL1 RR024131","U01HL146193","U01HL146192","U01 DA036935","R01 AG053100","P30 MH062246","K01AI093197","R01DA011602","P30 AI050409","P30AI027763","U01HL146245","U01 HL146333","U01HL146242","U01HL146241","U01HL146240","U01 AI069432","P30AI027767","U01 AI069434"],"pubmed_authors":["Rabkin CS","Mathews WC","Sterling TR","North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA)","Jenkins CA","Novak RM","Gill MJ","Christopher Mathews W","Achenbach CJ","Sudenga SL","Silverberg MJ","Kitahata MM","Wiley D","Sun J","Moore RD","Bian A","Shepherd BE","Castilho JL","Mayor AM","Napravnik S","Thorne JE","Bosch RJ","Sigel K","John Gill M","Marconi VC","Althoff KN","Coburn SB","Horberg MA"],"additional_accession":[]},"is_claimable":false,"name":"CD4/CD8 Ratio and Cancer Risk Among Adults With HIV.","description":"<h4>Background</h4>Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH) is associated with deleterious immune senescence, activation, and inflammation, which may contribute to carcinogenesis and excess cancer risk. We examined whether low CD4/CD8 ratios predicted cancer among PWH in the United States and Canada.<h4>Methods</h4>We examined all cancer-free PWH with 1 or more CD4/CD8 values from North American AIDS Cohort Collaboration on Research and Design observational cohorts with validated cancer diagnoses between 1998 and 2016. We evaluated the association between time-lagged CD4/CD8 ratio and risk of specific cancers in multivariable, time-updated Cox proportional hazard models using restricted cubic spines. Models were adjusted for age, sex, race and ethnicity, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-04T12:29:20.752Z","creation":"2025-04-19T13:31:11.07Z"},"accession":"S-EPMC9194634","cross_references":{"pubmed":["35292820"],"doi":["10.1093/jnci/djac053"]}}