biostudies-literatureCastilho JLNCATS NIH HHSNIDA NIH HHSNIA NIH HHSNCRR NIH HHSNIAID NIH HHSNHLBI NIH HHSNIMH NIH HHSNIAAA NIH HHSNational Institutes of HealthNEI NIH HHSNIMHD NIH HHSNCI NIH HHSNIGMS NIH HHS854-862https://www.ebi.ac.uk/biostudies/studies/S-EPMC9194634biostudies-literatureUnknown114(6)<h4>Background</h4>Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH) is associated with deleterious immune senescence, activation, and inflammation, which may contribute to carcinogenesis and excess cancer risk. We examined whether low CD4/CD8 ratios predicted cancer among PWH in the United States and Canada.<h4>Methods</h4>We examined all cancer-free PWH with 1 or more CD4/CD8 values from North American AIDS Cohort Collaboration on Research and Design observational cohorts with validated cancer diagnoses between 1998 and 2016. We evaluated the association between time-lagged CD4/CD8 ratio and risk of specific cancers in multivariable, time-updated Cox proportional hazard models using restricted cubic spines. Models were adjusted for age, sex, race and ethnicity, Journal of the National Cancer InstituteCD4/CD8 Ratio and Cancer Risk Among Adults With HIV.PMC9194634K01 AI131895K24 DA000432UL1 TR002378K23EY013707U01 AI038858U01 AI038855P30MH62246R24AI067039U01 HL146242R01 AA016893U01 HL146241U01 HL146240U01AI038855U01 HL146245U01AI038858U01AI069918UL1 TR000083F31DA037788K07 CA225404P30CA068485-23S3K23 EY013707P30 AI027767P30 AI027763F31 AI124794UL1 TR000004P30 CA068485U54 AG062334N02CP055504K23AI120875G12MD007583U01 HL146194U01 HL146193U01 HL146192R01DA012568K01 AI093197R34DA045592KL2TR000421P30 AI027757F31AI124794U10EY008052F31 DA037788G12 MD007583U24AA020794U01DA036935N01CP01004P30 AI094189R24 AI067039K24 AI065298U01AI069432U01 DA036297K01AI131895R01 DA012568N02CP91027U01HL146205U01HL146204U01HL146203U01HL146202U01HL146201U01 AI069918P30AI094189U01AA013566K24AI065298K24 AI118591UM1 AI068634U01 HL146205U01 HL146204KL2 TR000421U01 HL146203U01HL146208R01 DA011602U01 HL146208U01 AI068636U01 AA020790N02 CP055504U01 HL146202U10EY008067U01HL146333U01 HL146201K24AI118591K07CA225404U01AI069434U01 AI068634U10 EY008067U54 GM133807R01AA016893P30 AI036219U24 AA020794K23 AI120875P30AI036219K01 AI162247U10EY008057U01AI068636U01AA020790UM1 AI069432U01AI068634P30 AI050410U10 EY008057U01 AA013566P30 AI110527U01DA03629P01 AA029545K24DA000432P30AI050409U10 EY008052L30 AI133812R34 DA045592P30AI050410P30AI110527U01HL146194P30AI027757UL1 RR024131U01HL146193U01HL146192U01 DA036935R01 AG053100P30 MH062246K01AI093197R01DA011602P30 AI050409P30AI027763U01HL146245U01 HL146333U01HL146242U01HL146241U01HL146240U01 AI069432P30AI027767U01 AI069434Rabkin CSMathews WCSterling TRNorth American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA)Jenkins CANovak RMGill MJChristopher Mathews WAchenbach CJSudenga SLSilverberg MJKitahata MMWiley DSun JMoore RDBian AShepherd BECastilho JLMayor AMNapravnik SThorne JEBosch RJSigel KJohn Gill MMarconi VCAlthoff KNCoburn SBHorberg MAfalseCD4/CD8 Ratio and Cancer Risk Among Adults With HIV.<h4>Background</h4>Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH) is associated with deleterious immune senescence, activation, and inflammation, which may contribute to carcinogenesis and excess cancer risk. We examined whether low CD4/CD8 ratios predicted cancer among PWH in the United States and Canada.<h4>Methods</h4>We examined all cancer-free PWH with 1 or more CD4/CD8 values from North American AIDS Cohort Collaboration on Research and Design observational cohorts with validated cancer diagnoses between 1998 and 2016. We evaluated the association between time-lagged CD4/CD8 ratio and risk of specific cancers in multivariable, time-updated Cox proportional hazard models using restricted cubic spines. Models were adjusted for age, sex, race and ethnicity, 2022-01-01T00:00:00Z2022 Jun2026-06-04T12:29:20.752Z2025-04-19T13:31:11.07ZS-EPMC91946343529282010.1093/jnci/djac053