biostudies-literatureUnknown9Li YElevation of plasma creatinine after surgery is associated with postoperative morbidity and mortality. We studied whether lengthy surgery might induce renal conservation of water strong enough to exceed the renal capacity to excrete creatinine. Colorectal cancer surgery was performed via laparoscopy in 126 patients. Blood and urine were sampled before surgery, in the postoperative care unit, and 1 day after surgery. The Fluid Retention Index (FRI), which is a composite index of renal water conservation, was calculated. The mean FRI before surgery was 2.4, indicating that patients were well-hydrated. The FRI increased to 2.8 after surgery, and further to 3.5 on the first postoperative day. Plasma creatinine increased in 66 (52%) of the patients while plasma proteins were diluted by 15%. PatFrontiers in medicine837414https://www.ebi.ac.uk/biostudies/studies/S-EPMC9195291biostudies-literatureRenal Water Conservation and Plasma Creatinine in Colorectal Cancer Surgery: A Single-Group Clinical Study.PMC9195291Li YHu SHahn RGHe RfalseRenal Water Conservation and Plasma Creatinine in Colorectal Cancer Surgery: A Single-Group Clinical Study.Elevation of plasma creatinine after surgery is associated with postoperative morbidity and mortality. We studied whether lengthy surgery might induce renal conservation of water strong enough to exceed the renal capacity to excrete creatinine. Colorectal cancer surgery was performed via laparoscopy in 126 patients. Blood and urine were sampled before surgery, in the postoperative care unit, and 1 day after surgery. The Fluid Retention Index (FRI), which is a composite index of renal water conservation, was calculated. The mean FRI before surgery was 2.4, indicating that patients were well-hydrated. The FRI increased to 2.8 after surgery, and further to 3.5 on the first postoperative day. Plasma creatinine increased in 66 (52%) of the patients while plasma proteins were diluted by 15%. Pat2022-01-01T00:00:00Z20222025-04-22T06:00:29.114Z2024-11-12T10:57:00.418ZS-EPMC91952913571208810.3389/fmed.2022.837414