{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Wang A"],"pubmed_abstract":["<h4>Purpose</h4><i>Salvia miltiorrhiza Bge.</i> (Danshen, DS) and <i>Ligusticum chuanxiong Hort.</i> (Chuanxiong, CX) have been widely used in traditional Chinese medicine to prevent and treat myocardial ischemia and renal insufficiency, and their extracts (Guanxinning injection, GXN) have been reported to exhibit antioxidant, anti-inflammatory, and anti-ischemia-reperfusion injury properties. It is well-established that ischemic postconditioning (IPOC) can protect against myocardial ischemia-reperfusion (I/R) injury in rats with chronic renal failure (CRF). However, little is known on whether GXN combined with IPOC may affect myocardial I/R injury in CRF rats. We sought to observe the effect of GXN combined with IPOC on myocardial I/R injury in CRF rats by quantifying changes in the expre"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["905254"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9196273"],"repository":["biostudies-literature"],"pubmed_title":["Guanxinning Injection Combined With Ischemic Postconditioning Attenuate Myocardial Ischemic Reperfusion Injury in Chronic Renal Failure Rats by Modulating Mitochondrial Dynamics."],"pmcid":["PMC9196273"],"pubmed_authors":["Liu J","Zhang D","Wang A","Ma X","Yuan H","Yan H","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Guanxinning Injection Combined With Ischemic Postconditioning Attenuate Myocardial Ischemic Reperfusion Injury in Chronic Renal Failure Rats by Modulating Mitochondrial Dynamics.","description":"<h4>Purpose</h4><i>Salvia miltiorrhiza Bge.</i> (Danshen, DS) and <i>Ligusticum chuanxiong Hort.</i> (Chuanxiong, CX) have been widely used in traditional Chinese medicine to prevent and treat myocardial ischemia and renal insufficiency, and their extracts (Guanxinning injection, GXN) have been reported to exhibit antioxidant, anti-inflammatory, and anti-ischemia-reperfusion injury properties. It is well-established that ischemic postconditioning (IPOC) can protect against myocardial ischemia-reperfusion (I/R) injury in rats with chronic renal failure (CRF). However, little is known on whether GXN combined with IPOC may affect myocardial I/R injury in CRF rats. We sought to observe the effect of GXN combined with IPOC on myocardial I/R injury in CRF rats by quantifying changes in the expre","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T05:55:09.032Z","creation":"2025-04-05T21:34:25.301Z"},"accession":"S-EPMC9196273","cross_references":{"pubmed":["35711377"],"doi":["10.3389/fcvm.2022.905254"]}}