{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Ma X"],"pubmed_abstract":["The development of heteronuclear metal complexes as potent anticancer agents has received increasing attention in recent years. In this study, two new heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes, [Ru(bpy)<sub>2</sub>LRe(CO)<sub>3</sub>(DIP)](PF<sub>6</sub>)<sub>3</sub> and [Ru(phen)<sub>2</sub>LRe(CO)<sub>3</sub>(DIP)](PF<sub>6</sub>)<sub>3</sub> [<b>RuRe-1</b> and <b>RuRe-2</b>, L = 2-(4-pyridinyl)imidazolio[4,5-f][1,10]phenanthroline, bpy = 2,2'-bipyridine, DIP = 4,7-diphenyl-1,10-phenanthroline, phen = 1,10-phenanthroline], were synthesized and characterized. Cytotoxicity assay shows that <b>RuRe-1</b> and <b>RuRe-2</b> exhibit higher anticancer activity than cisplatin, and exist certain selectivity toward human cancer cells over normal cells. The anticancer mechanistic studies reveal tha"],"journal":["Frontiers in chemistry"],"pagination":["890925"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9196629"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes."],"pmcid":["PMC9196629"],"pubmed_authors":["Lu J","Ye R","Ma X","Yang P","Li R","Huang B"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes.","description":"The development of heteronuclear metal complexes as potent anticancer agents has received increasing attention in recent years. In this study, two new heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes, [Ru(bpy)<sub>2</sub>LRe(CO)<sub>3</sub>(DIP)](PF<sub>6</sub>)<sub>3</sub> and [Ru(phen)<sub>2</sub>LRe(CO)<sub>3</sub>(DIP)](PF<sub>6</sub>)<sub>3</sub> [<b>RuRe-1</b> and <b>RuRe-2</b>, L = 2-(4-pyridinyl)imidazolio[4,5-f][1,10]phenanthroline, bpy = 2,2'-bipyridine, DIP = 4,7-diphenyl-1,10-phenanthroline, phen = 1,10-phenanthroline], were synthesized and characterized. Cytotoxicity assay shows that <b>RuRe-1</b> and <b>RuRe-2</b> exhibit higher anticancer activity than cisplatin, and exist certain selectivity toward human cancer cells over normal cells. The anticancer mechanistic studies reveal tha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T05:59:25.959Z","creation":"2025-04-05T21:32:29.421Z"},"accession":"S-EPMC9196629","cross_references":{"pubmed":["35711955"],"doi":["10.3389/fchem.2022.890925"]}}