{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Olguin-Martinez E"],"pubmed_abstract":["Type 2 Innate lymphoid cells (ILC2s) are tissue-resident immune cells activated by epithelial-derived alarmins upon tissue damage. They regulate immunity against helminth parasites and allergies by expressing type 2 immune response cytokines including IL-9, known to be critical for inducing and potentiating the immune response in such context. Although ILC2s are reported to be the main source of IL-9 in mice during <i>N. brasiliensis</i> infection, the mechanisms that regulate the expression of IL-9 in these cells are yet to be described. Recent studies have shown that in addition to cytokines, multiple molecules can differentially modulate the functions of ILC2s in various contexts both <i>in vitro</i> and <i>in vivo</i>. Among these stimuli are lipid mediators and neuropeptides, which ac"],"journal":["Frontiers in immunology"],"pagination":["787713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9197159"],"repository":["biostudies-literature"],"pubmed_title":["IL-33 and the PKA Pathway Regulate ILC2 Populations Expressing IL-9 and ST2."],"pmcid":["PMC9197159"],"pubmed_authors":["Licona-Limon P","Ramos-Balderas JL","Ruiz-Medina BE","Licona-Limon I","Olguin-Martinez E","Munoz-Paleta O"],"additional_accession":[]},"is_claimable":false,"name":"IL-33 and the PKA Pathway Regulate ILC2 Populations Expressing IL-9 and ST2.","description":"Type 2 Innate lymphoid cells (ILC2s) are tissue-resident immune cells activated by epithelial-derived alarmins upon tissue damage. They regulate immunity against helminth parasites and allergies by expressing type 2 immune response cytokines including IL-9, known to be critical for inducing and potentiating the immune response in such context. Although ILC2s are reported to be the main source of IL-9 in mice during <i>N. brasiliensis</i> infection, the mechanisms that regulate the expression of IL-9 in these cells are yet to be described. Recent studies have shown that in addition to cytokines, multiple molecules can differentially modulate the functions of ILC2s in various contexts both <i>in vitro</i> and <i>in vivo</i>. Among these stimuli are lipid mediators and neuropeptides, which ac","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-08-12T03:04:37.78Z","creation":"2025-04-04T19:06:40.324Z"},"accession":"S-EPMC9197159","cross_references":{"pubmed":["35711429"],"doi":["10.3389/fimmu.2022.787713"]}}