{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arany Z"],"funding":["NHLBI NIH HHS"],"pagination":["1763-1779"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9199836"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["130(12)"],"pubmed_abstract":["Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease."],"journal":["Circulation research"],"pubmed_title":["Animal Models of Cardiovascular Complications of Pregnancy."],"pmcid":["PMC9199836"],"funding_grant_id":["R01 HL152446","R01 HL126797"],"pubmed_authors":["Hilfiker-Kleiner D","Karumanchi SA","Arany Z"],"additional_accession":[]},"is_claimable":false,"name":"Animal Models of Cardiovascular Complications of Pregnancy.","description":"Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T10:21:49.67Z","creation":"2025-02-19T02:38:07.577Z"},"accession":"S-EPMC9199836","cross_references":{"pubmed":["35679359"],"doi":["10.1161/CIRCRESAHA.122.320395","10.1161/circresaha.122.320395"]}}