biostudies-literatureArany ZNHLBI NIH HHS1763-1779https://www.ebi.ac.uk/biostudies/studies/S-EPMC9199836biostudies-literatureUnknown130(12)Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.Circulation researchAnimal Models of Cardiovascular Complications of Pregnancy.PMC9199836R01 HL152446R01 HL126797Hilfiker-Kleiner DKarumanchi SAArany ZfalseAnimal Models of Cardiovascular Complications of Pregnancy.Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.2022-01-01T00:00:00Z2022 Jun2025-04-04T10:21:49.67Z2025-02-19T02:38:07.577ZS-EPMC91998363567935910.1161/CIRCRESAHA.122.32039510.1161/circresaha.122.320395