{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(10)"],"submitter":["Xie X"],"pubmed_abstract":["<h4>Background</h4>Numerous studies indicate that long noncoding RNA (lncRNA) is aberrantly expressed in ovarian cancer (OC). Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR-505-3p/ZNF326 axis.<h4>Methods</h4>Expression of <i>KTN1-AS1</i>, microRNA-505-3p (<i>miR-505-3p</i>), and zinc-finger protein-326 (<i>ZNF326</i>) in OC was evaluated by using RT-qPCR analysis. The biological function of <i>KTN1-AS1</i> was inspected using the loss-of-function assay. Luciferase reporter assay and RIP assay were performed to determine the competitive endogenous RNA (ceRNA) network of <i>KTN1-AS1</i>/<i>miR-505-3p</i>/<i>ZNF326</i>.<h4>Results</h4>The data showed that <i>KTN1-AS1</i> and <i>ZNF326</i> had a high expression in"],"journal":["Annals of translational medicine"],"pagination":["599"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9201172"],"repository":["biostudies-literature"],"pubmed_title":["H3K27ac-activated lncRNA KTN1-AS1 aggravates tumor progression by miR-505-3p/ZNF326 axis in ovarian cancer."],"pmcid":["PMC9201172"],"pubmed_authors":["Yang X","Liu Y","Zhang T","Xie X","Wen Q","Chen W","Xu C","Shi K","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"H3K27ac-activated lncRNA KTN1-AS1 aggravates tumor progression by miR-505-3p/ZNF326 axis in ovarian cancer.","description":"<h4>Background</h4>Numerous studies indicate that long noncoding RNA (lncRNA) is aberrantly expressed in ovarian cancer (OC). Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR-505-3p/ZNF326 axis.<h4>Methods</h4>Expression of <i>KTN1-AS1</i>, microRNA-505-3p (<i>miR-505-3p</i>), and zinc-finger protein-326 (<i>ZNF326</i>) in OC was evaluated by using RT-qPCR analysis. The biological function of <i>KTN1-AS1</i> was inspected using the loss-of-function assay. Luciferase reporter assay and RIP assay were performed to determine the competitive endogenous RNA (ceRNA) network of <i>KTN1-AS1</i>/<i>miR-505-3p</i>/<i>ZNF326</i>.<h4>Results</h4>The data showed that <i>KTN1-AS1</i> and <i>ZNF326</i> had a high expression in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-27T03:15:19.871Z","creation":"2025-04-06T18:45:34.387Z"},"accession":"S-EPMC9201172","cross_references":{"pubmed":["35722429"],"doi":["10.21037/atm-22-443"]}}