biostudies-literatureUnknown10(10)Xie X<h4>Background</h4>Numerous studies indicate that long noncoding RNA (lncRNA) is aberrantly expressed in ovarian cancer (OC). Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR-505-3p/ZNF326 axis.<h4>Methods</h4>Expression of <i>KTN1-AS1</i>, microRNA-505-3p (<i>miR-505-3p</i>), and zinc-finger protein-326 (<i>ZNF326</i>) in OC was evaluated by using RT-qPCR analysis. The biological function of <i>KTN1-AS1</i> was inspected using the loss-of-function assay. Luciferase reporter assay and RIP assay were performed to determine the competitive endogenous RNA (ceRNA) network of <i>KTN1-AS1</i>/<i>miR-505-3p</i>/<i>ZNF326</i>.<h4>Results</h4>The data showed that <i>KTN1-AS1</i> and <i>ZNF326</i> had a high expression inAnnals of translational medicine599https://www.ebi.ac.uk/biostudies/studies/S-EPMC9201172biostudies-literatureH3K27ac-activated lncRNA KTN1-AS1 aggravates tumor progression by miR-505-3p/ZNF326 axis in ovarian cancer.PMC9201172Yang XLiu YZhang TXie XWen QChen WXu CShi KLiu WfalseH3K27ac-activated lncRNA KTN1-AS1 aggravates tumor progression by miR-505-3p/ZNF326 axis in ovarian cancer.<h4>Background</h4>Numerous studies indicate that long noncoding RNA (lncRNA) is aberrantly expressed in ovarian cancer (OC). Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR-505-3p/ZNF326 axis.<h4>Methods</h4>Expression of <i>KTN1-AS1</i>, microRNA-505-3p (<i>miR-505-3p</i>), and zinc-finger protein-326 (<i>ZNF326</i>) in OC was evaluated by using RT-qPCR analysis. The biological function of <i>KTN1-AS1</i> was inspected using the loss-of-function assay. Luciferase reporter assay and RIP assay were performed to determine the competitive endogenous RNA (ceRNA) network of <i>KTN1-AS1</i>/<i>miR-505-3p</i>/<i>ZNF326</i>.<h4>Results</h4>The data showed that <i>KTN1-AS1</i> and <i>ZNF326</i> had a high expression in2022-01-01T00:00:00Z2022 May2025-04-27T03:15:19.871Z2025-04-06T18:45:34.387ZS-EPMC92011723572242910.21037/atm-22-443