{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(2)"],"submitter":["Tang Y"],"pubmed_abstract":["Our previous study reported that clinical features, including the lateral/ventral tongue and non-homogeneous lesions, were associated with increased risk of malignant changes in cytological samples from oral potentially malignant disorders (OPMDs). This cross-sectional study aimed to evaluate the frequency and risk of DNA aneuploidy in the series of 748 patients with OPMD. The cut-off value of aneuploidy was defined as DNA index ≥3.5. We found that the frequency of DNA aneuploidy was higher in OPMD patients >60 years old, and in those with lateral/ventral tongue sites, non-homogeneous lesions, and high-grade dysplasia, than in control group (<i>P</i> < 0.01). Consistently, the risk of aneuploidy occurrence was higher in patients >60 years old (1.69-fold; <i>P</i> = 0.022), in those with la"],"journal":["Journal of dental sciences"],"pagination":["1035-1038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9201530"],"repository":["biostudies-literature"],"pubmed_title":["Relationship of DNA aneuploidy with distinctive features of oral potentially malignant disorders: A cytological analysis of 748 cases."],"pmcid":["PMC9201530"],"pubmed_authors":["Shi L","Liu L","Li C","Tang Y","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Relationship of DNA aneuploidy with distinctive features of oral potentially malignant disorders: A cytological analysis of 748 cases.","description":"Our previous study reported that clinical features, including the lateral/ventral tongue and non-homogeneous lesions, were associated with increased risk of malignant changes in cytological samples from oral potentially malignant disorders (OPMDs). This cross-sectional study aimed to evaluate the frequency and risk of DNA aneuploidy in the series of 748 patients with OPMD. The cut-off value of aneuploidy was defined as DNA index ≥3.5. We found that the frequency of DNA aneuploidy was higher in OPMD patients >60 years old, and in those with lateral/ventral tongue sites, non-homogeneous lesions, and high-grade dysplasia, than in control group (<i>P</i> < 0.01). Consistently, the risk of aneuploidy occurrence was higher in patients >60 years old (1.69-fold; <i>P</i> = 0.022), in those with la","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T11:51:21.751Z","creation":"2025-04-05T11:51:21.751Z"},"accession":"S-EPMC9201530","cross_references":{"pubmed":["35756767"],"doi":["10.1016/j.jds.2021.10.010"]}}