biostudies-literatureUnknown17(2)Tang YOur previous study reported that clinical features, including the lateral/ventral tongue and non-homogeneous lesions, were associated with increased risk of malignant changes in cytological samples from oral potentially malignant disorders (OPMDs). This cross-sectional study aimed to evaluate the frequency and risk of DNA aneuploidy in the series of 748 patients with OPMD. The cut-off value of aneuploidy was defined as DNA index ≥3.5. We found that the frequency of DNA aneuploidy was higher in OPMD patients >60 years old, and in those with lateral/ventral tongue sites, non-homogeneous lesions, and high-grade dysplasia, than in control group (<i>P</i> < 0.01). Consistently, the risk of aneuploidy occurrence was higher in patients >60 years old (1.69-fold; <i>P</i> = 0.022), in those with laJournal of dental sciences1035-1038https://www.ebi.ac.uk/biostudies/studies/S-EPMC9201530biostudies-literatureRelationship of DNA aneuploidy with distinctive features of oral potentially malignant disorders: A cytological analysis of 748 cases.PMC9201530Shi LLiu LLi CTang YLiu WfalseRelationship of DNA aneuploidy with distinctive features of oral potentially malignant disorders: A cytological analysis of 748 cases.Our previous study reported that clinical features, including the lateral/ventral tongue and non-homogeneous lesions, were associated with increased risk of malignant changes in cytological samples from oral potentially malignant disorders (OPMDs). This cross-sectional study aimed to evaluate the frequency and risk of DNA aneuploidy in the series of 748 patients with OPMD. The cut-off value of aneuploidy was defined as DNA index ≥3.5. We found that the frequency of DNA aneuploidy was higher in OPMD patients >60 years old, and in those with lateral/ventral tongue sites, non-homogeneous lesions, and high-grade dysplasia, than in control group (<i>P</i> < 0.01). Consistently, the risk of aneuploidy occurrence was higher in patients >60 years old (1.69-fold; <i>P</i> = 0.022), in those with la2022-01-01T00:00:00Z2022 Apr2025-04-05T11:51:21.751Z2025-04-05T11:51:21.751ZS-EPMC92015303575676710.1016/j.jds.2021.10.010