{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muller GA"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["2909-2919"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9201786"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(21)"],"pubmed_abstract":["Proper progression through the cell-division cycle is critical to normal development and homeostasis and is necessarily misregulated in cancer. The key to cell-cycle regulation is the control of two waves of transcription that occur at the onset of DNA replication (S phase) and mitosis (M phase). MuvB complexes play a central role in the regulation of these genes. When cells are not actively dividing, the MuvB complex DREAM represses G1/S and G2/M genes. Remarkably, MuvB also forms activator complexes together with the oncogenic transcription factors B-MYB and FOXM1 that are required for the expression of the mitotic genes in G2/M. Despite this essential role in the control of cell division and the relationship to cancer, it has been unclear how MuvB complexes inhibit and stimulate gene ex"],"journal":["Oncogene"],"pubmed_title":["Structure and function of MuvB complexes."],"pmcid":["PMC9201786"],"funding_grant_id":["R01 GM124148","R01 GM127707","R01GM127707","T32 CA009302","R01 CA228413"],"pubmed_authors":["Asthana A","Rubin SM","Muller GA"],"additional_accession":[]},"is_claimable":false,"name":"Structure and function of MuvB complexes.","description":"Proper progression through the cell-division cycle is critical to normal development and homeostasis and is necessarily misregulated in cancer. The key to cell-cycle regulation is the control of two waves of transcription that occur at the onset of DNA replication (S phase) and mitosis (M phase). MuvB complexes play a central role in the regulation of these genes. When cells are not actively dividing, the MuvB complex DREAM represses G1/S and G2/M genes. Remarkably, MuvB also forms activator complexes together with the oncogenic transcription factors B-MYB and FOXM1 that are required for the expression of the mitotic genes in G2/M. Despite this essential role in the control of cell division and the relationship to cancer, it has been unclear how MuvB complexes inhibit and stimulate gene ex","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T22:33:37.14Z","creation":"2025-02-19T03:23:50.391Z"},"accession":"S-EPMC9201786","cross_references":{"pubmed":["35468940"],"doi":["10.1038/s41388-022-02321-x"]}}