{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Collier A"],"funding":["NCRR NIH HHS","NCI NIH HHS","NIAMS NIH HHS"],"pagination":["188-196"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9202145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["606(7912)"],"pubmed_abstract":["Proper ectodermal patterning during human development requires previously identified transcription factors such as GATA3 and p63, as well as positional signalling from regional mesoderm<sup>1-6</sup>. However, the mechanism by which ectoderm and mesoderm factors act to stably pattern gene expression and lineage commitment remains unclear. Here we identify the protein Gibbin, encoded by the Xia-Gibbs AT-hook DNA-binding-motif-containing 1 (AHDC1) disease gene<sup>7-9</sup>, as a key regulator of early epithelial morphogenesis. We find that enhancer- or promoter-bound Gibbin interacts with dozens of sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes. The loss of Gibbin causes an increase in DNA methylation at GATA3"],"journal":["Nature"],"pubmed_title":["Gibbin mesodermal regulation patterns epithelial development."],"pmcid":["PMC9202145"],"funding_grant_id":["R01 AR054780","S10 RR025518","P30 CA124435","R01 AR073170","F32 AR074221"],"pubmed_authors":["Oro AE","Torkelson J","Zhen H","Collier A","Patel T","Pattison J","McCarthy K","Liu A","Gaddam S","Ghanim H"],"additional_accession":[]},"is_claimable":false,"name":"Gibbin mesodermal regulation patterns epithelial development.","description":"Proper ectodermal patterning during human development requires previously identified transcription factors such as GATA3 and p63, as well as positional signalling from regional mesoderm<sup>1-6</sup>. However, the mechanism by which ectoderm and mesoderm factors act to stably pattern gene expression and lineage commitment remains unclear. Here we identify the protein Gibbin, encoded by the Xia-Gibbs AT-hook DNA-binding-motif-containing 1 (AHDC1) disease gene<sup>7-9</sup>, as a key regulator of early epithelial morphogenesis. We find that enhancer- or promoter-bound Gibbin interacts with dozens of sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes. The loss of Gibbin causes an increase in DNA methylation at GATA3","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-09T14:12:58.97Z","creation":"2025-04-06T14:07:17.237Z"},"accession":"S-EPMC9202145","cross_references":{"pubmed":["35585237"],"doi":["10.1038/s41586-022-04727-9"]}}