biostudies-literatureOrtega MMCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorMinistry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e TecnológicoFundação de Amparo à Pesquisa do Estado de São Pauloo10125https://www.ebi.ac.uk/biostudies/studies/S-EPMC9202665biostudies-literatureUnknown12(1)We investigated the anti-SARS-CoV-2 post-vaccine response through serum and salivary antibodies, serum antibody neutralizing activity and cellular immune response in samples from health care workers who were immunized with two doses of an inactivated virus-based vaccine (CoronaVac) who had or did not have COVID-19 previously. IgA and IgG antibodies directed at the spike protein were analysed in samples of saliva and/or serum by ELISA and/or chemiluminescence assays; the neutralizing activity of serum antibodies against reference strain B, Gamma and Delta SARS-CoV-2 variants were evaluated using a virus neutralization test and SARS-CoV-2 reactive interferon-gamma T-cell were analysed by flow cytometry. CoronaVac was able to induce serum and salivary IgG anti-spike antibodies and IFN-γ produScientific reportsSalivary, serological, and cellular immune response to the CoronaVac vaccine in health care workers with or without previous COVID-19.PMC92026652019/24849-12018/12460-0380453/2022-3380286/2022-02014/50489-9380279/2022-32020/06409-1380454/2022-088887.472042/2019-00302945/2019-92016/25212-9305135/2019888887.511267/2020-002021/06139-7Oliveira DBLZheng YScagion GPChalup VNLeal FBOshiro TMde Almeida ACandido EDDurigon ELPalmeira Pda Silva Duarte AJCorrea-Silva SCora APTiyo BTCeneviva Cda Silva LTCarneiro-Sampaio MOrtega MMFerreira AEFValerio CASchmitz GJHfalseSalivary, serological, and cellular immune response to the CoronaVac vaccine in health care workers with or without previous COVID-19.We investigated the anti-SARS-CoV-2 post-vaccine response through serum and salivary antibodies, serum antibody neutralizing activity and cellular immune response in samples from health care workers who were immunized with two doses of an inactivated virus-based vaccine (CoronaVac) who had or did not have COVID-19 previously. IgA and IgG antibodies directed at the spike protein were analysed in samples of saliva and/or serum by ELISA and/or chemiluminescence assays; the neutralizing activity of serum antibodies against reference strain B, Gamma and Delta SARS-CoV-2 variants were evaluated using a virus neutralization test and SARS-CoV-2 reactive interferon-gamma T-cell were analysed by flow cytometry. CoronaVac was able to induce serum and salivary IgG anti-spike antibodies and IFN-γ produ2022-01-01T00:00:00Z2022 Jun2025-05-29T22:25:00.05Z2024-11-09T12:41:31.167ZS-EPMC92026653571057310.1038/s41598-022-14283-x