biostudies-literatureUnknown17(6)Liisborg CRegion Zealand&apos;s research promotion fundFight for Sight Denmark<h4>Purpose</h4>Peripheral T cell CXCR3 expression has been found uniquely lower in patients having neovascular age-related macular degeneration (nAMD) than in healthy individuals. The CXCR3-axis has been shown to have angiostatic and antifibrotic properties. We have recently investigated systemic markers in patients with myeloproliferative neoplasms (MPNs) because of their higher prevalence of AMD, and we have observed higher systemic chronic low-grade inflammation and immunosenescence signs in MPNs with drusen (MPNd) compared to those with normal retinas (MPNn). The MPNs evolve in a biological continuum from early cancer-stages (essential thrombocytosis, polycythemia vera) to the advanced myelofibrosis stage. Especially myelofibrosis is characterized by bone marrow angiogenesis and fibroPloS onee0269960https://www.ebi.ac.uk/biostudies/studies/S-EPMC9202899biostudies-literatureLower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers.PMC9202899Kjær LLykke Sorensen TLiisborg CSkov VHasselbalch HCfalseLower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers.<h4>Purpose</h4>Peripheral T cell CXCR3 expression has been found uniquely lower in patients having neovascular age-related macular degeneration (nAMD) than in healthy individuals. The CXCR3-axis has been shown to have angiostatic and antifibrotic properties. We have recently investigated systemic markers in patients with myeloproliferative neoplasms (MPNs) because of their higher prevalence of AMD, and we have observed higher systemic chronic low-grade inflammation and immunosenescence signs in MPNs with drusen (MPNd) compared to those with normal retinas (MPNn). The MPNs evolve in a biological continuum from early cancer-stages (essential thrombocytosis, polycythemia vera) to the advanced myelofibrosis stage. Especially myelofibrosis is characterized by bone marrow angiogenesis and fibro2022-01-01T00:00:00Z20222025-04-05T13:32:56.143Z2024-10-18T16:48:43.805ZS-EPMC92028993570917710.1371/journal.pone.0269960