{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jun SW"],"funding":["National Research Foundation of Korea"],"pagination":["3470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9203813"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["In this study, we perform a thermal curve analysis with terahertz (THz) metamaterials to develop a label-free identification tool for pathogens such as bacteria and yeasts. The resonant frequency of the metasensor coated with a bacterial layer changes as a function of temperature; this provides a unique fingerprint specific to the individual microbial species without the use of fluorescent dyes and antibodies. Differential thermal curves obtained from the temperature-dependent resonance exhibit the peaks consistent with bacterial phases, such as growth, thermal inactivation, DNA denaturation, and cell wall destruction. In addition, we can distinguish gram-negative bacteria from gram-positive bacteria which show strong peaks in the temperature range of cell wall destruction. Finally, we per"],"journal":["Nature communications"],"pubmed_title":["Terahertz thermal curve analysis for label-free identification of pathogens."],"pmcid":["PMC9203813"],"funding_grant_id":["2020R1A2C1005735","2021R1A6A1A10044950"],"pubmed_authors":["Jun SW","Ahn YH"],"additional_accession":[]},"is_claimable":false,"name":"Terahertz thermal curve analysis for label-free identification of pathogens.","description":"In this study, we perform a thermal curve analysis with terahertz (THz) metamaterials to develop a label-free identification tool for pathogens such as bacteria and yeasts. The resonant frequency of the metasensor coated with a bacterial layer changes as a function of temperature; this provides a unique fingerprint specific to the individual microbial species without the use of fluorescent dyes and antibodies. Differential thermal curves obtained from the temperature-dependent resonance exhibit the peaks consistent with bacterial phases, such as growth, thermal inactivation, DNA denaturation, and cell wall destruction. In addition, we can distinguish gram-negative bacteria from gram-positive bacteria which show strong peaks in the temperature range of cell wall destruction. Finally, we per","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T03:06:17.901Z","creation":"2025-02-19T05:06:15.181Z"},"accession":"S-EPMC9203813","cross_references":{"pubmed":["35710797"],"doi":["10.1038/s41467-022-31137-2"]}}